Rodent roundup
SAGE Labs has announced a new partnership with the autism science and advocacy organization Autism Speaks to fund the creation of three new rat models of autism.
SAGE Labs has announced a new partnership with the autism science and advocacy organization Autism Speaks to fund the creation of three new rat models of autism.
Delicate dosage issues are just one complication of developing gene therapy for neurodevelopmental disorders.
The gene missing or mutated in Rett syndrome, an autism spectrum disorder, is critical for the survival of adult mice, according to a study published 31 May in Human Molecular Genetics.
Two new postmortem studies show that microglia, which protect the brain from invaders, are denser and more concentrated around neurons in the brains of individuals with autism than in those of controls.
A pilot project highlights how adult stem cells could be used to test and select personalized therapies.
As the use of induced pluripotent stem cells grows, researchers are searching for ways to make them behave more predictably.
Individuals with autism are more likely than controls to have small, rare duplications or deletions of stretches of DNA in genes that play a role in dampening signals in the brain, according to a study published 2 April in Molecular Autism.
In the last three years, autism researchers have gone from sequencing single genes to whole exomes, as highlighted at the Translational Neuroscience Symposium in Switzerland last week.
Two studies report abnormalities in the system that mediates the body’s response to stress in two mouse models of autism-related diseases: Angelman syndrome and Rett syndrome. The results were published in the April issue of Human Molecular Genetics.
Mutant mice with autism-like behaviors have fewer behavioral impairments when provided with toys, exercise wheels and contact with other mice, than do those that live in typical laboratory cages, according to a study published 5 April in Human Molecular Genetics.