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Tag: Rett syndrome

November 2010
News

Rett gene needed to stabilize synaptic strength

by  /  16 November 2010

Blocking the expression of the MeCP2 gene decreases the number of synapses, the junctions between neurons. It also prevents synapses from scaling up their activity to make up for the loss, according to unpublished data shown yesterday at the Society for Neuroscience annual meeting in San Diego.

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News

Stem cells reveal neuroligin’s role in development

by  /  15 November 2010

Stem cell studies show that a mutation in the neuroligin-4 gene disrupts the normal development of synapses, the junction between neurons, according to unpublished data shown Sunday at the Society for Neuroscience annual meeting in San Diego.

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News

Researchers debut new mouse model for Rett syndrome

by  /  11 November 2010

A new mouse model for Rett syndrome shows that disrupting a single brain messenger can produce nearly all of the characteristic features of the syndrome, researchers report today in Nature.

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October 2010
News

Genetics: Sibling study delivers new autism candidates

by  /  22 October 2010

People with autism show differences in the levels of various gene products compared with their unaffected siblings, according to a study published online in September in Brain Research.

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Opinion

Crossover potential?

by  /  18 October 2010

“I don’t know anything about Williams syndrome”: That isn’t exactly how you’d expect a talk at a meeting on the syndrome to begin, but it happened more than once at a symposium on the disorder last week. Could scientific interchange between Williams syndrome and autism researchers benefit people with either condition?

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September 2010
News

Molecular mechanisms: Autism brains show ‘angry’ microglia

by  /  27 September 2010

A study of postmortem tissue shows that microglia, cells that provide immune protection to the brain, are altered in the brains of individuals with autism.

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June 2010
News

Rett gene function extends beyond neurons, study finds

by  /  15 June 2010

Microglia, brain cells that provide immune protection to neurons, may influence the onset and course of Rett syndrome, according to a study published in the Journal of Neuroscience.

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April 2010
Opinion

Measuring expression

by  /  14 April 2010

To examine protein interactions inside brain cells, scientists typically zero in on one gene at a time. A new method described in today’s Nature simultaneously measures expression of the whole genome.

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News

Random genetic changes may explain variability in autism

by  /  13 April 2010

Random changes in gene expression can cause genetically identical embryos to develop different traits, according to a study of worms published in Nature. The findings suggest that haphazard movements of molecules could partly explain why autism-associated mutations don’t always cause the same symptoms.

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News

Rett gene found to control genome structure in neurons

by  /  9 April 2010

The protein that is mutated in Rett syndrome controls the expression of other genes by changing the way DNA packs into a cell, rather than turning genes on or off, according to a study published in Molecular Cell.

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