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Tag: Rett syndrome

October 2021
Black CDKL5 mice in a lab setting--three mice in a cage.
News

Brain stimulation improves memory in autism mouse models

by  /  15 October 2021

Jolting a bundle of nerve fibers deep in the brain restores learning and memory in mice with mutations of the autism-linked gene CDKL5.

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July 2021
Colorful, playful illustrated scene of ewborns on a conveyor belt moving past researchers holding a long, long list.
News

The push to screen newborns for rare autism-linked genetic conditions

by  /  28 July 2021

As treatments for some autism-linked genetic conditions inch closer to the clinic, researchers are talking more urgently about screening all newborns for such conditions.

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June 2021
Dr. Huda Zoghbi portrait
News / Profiles

Huda Zoghbi: Taking genetic inquiry to the next level

by  /  25 June 2021

Over the course of a career spanning more than three decades, Huda Zoghbi has won almost every major biology and neuroscience research award that exists. More than 20 years since she discovered the gene behind Rett syndrome, she remains laser focused on unlocking the condition’s secrets and finding effective treatments.

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lab technician pipetting in dramatic light
News

Alternative gene-therapy approaches take aim at Rett syndrome

by  /  16 June 2021

Methods that selectively increase levels of the Rett protein make for safer and more effective treatment strategies, some researchers say.

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March 2021
Mouse brain neurons labeled with a genetic marker show pink on a dramatic blue background.
News

Early training forestalls motor, memory difficulties in mouse model of Rett syndrome

by  /  24 March 2021

Motor and memory training early in life postpones the onset of difficulties in those areas in a mouse model of Rett syndrome, and stimulating neurons involved in those skills appears to mimic the effects of training.

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News

Broken protein bridge linked to Rett syndrome traits

by  /  1 March 2021

Altering a protein linked to Rett syndrome so that it cannot bind to a methylation tag in neurons results in Rett-like traits in mice.

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February 2021
cells in a mouse brain show the mutations in green.
News / Toolbox

Molecular switch marks mosaic mutations in mice

by  /  11 February 2021

A new tool enables researchers to create mosaic mutations in only some cells and then accurately identify which cells are affected.

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January 2021
News / Toolbox

Method may improve safety of gene therapies targeting the brain

by  /  28 January 2021

A new approach for delivering gene therapy to the brain reduces nerve damage in primates and could help make gene therapies for conditions related to autism safer.

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DNMT3A protein attaches a methyl group tag onto the DNA base cytosine.
News

Autism-related conditions converge on same loss of DNA tags

by  /  20 January 2021

Mutations in the autism-linked gene DNMT3A lead to the behaviors and gene-expression changes seen in different neurodevelopmental conditions.

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Mouse with her pup
News

Malfunctioning neurons mute sound processing in mouse model of Rett syndrome

by  /  14 January 2021

Female mice missing a copy of the autism-linked gene MECP2 in a specific set of inhibitory neurons have a hard time heeding pups’ calls and herding litters.

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