Clinical research: Mainstreaming helps children with autism
Early interventions for preschoolers who have autism are effective when included alongside standard curricula in mainstream settings, according to two studies published in April.
Early interventions for preschoolers who have autism are effective when included alongside standard curricula in mainstream settings, according to two studies published in April.
Three new studies analyzing genetic data from families in which just one child has autism have found the strongest evidence yet that rare new mutations contribute to the disorder.
Children with autism have fewer DNA modifications that regulate gene expression compared with healthy siblings and controls, and show evidence of DNA damage, according to a study published 26 April in the Journal of Autism and Developmental Disorders.
Deletions on a segment of chromosome 11 are associated with autism, attention problems and obesity, according to a study published in the June issue of the American Journal of Medical Genetics Part A.
People with autism are highly adept at detecting symmetry in patterns, according to a study published 29 April in PLoS ONE.
Mice with a mutation in SHANK3, a leading autism candidate gene, show moderate social defects, including less-than-normal interest in other mice. The findings, published 27 May in Cell, suggest that mutations in different sites on the gene can lead to different behaviors. This paper was retracted on 17 January 2013. Associate director of research Alan Packer discusses the implications of the retraction here.
A new study provides the first functional link between the schizophrenia risk gene DISC1 and two candidate genes for autism. DISC1 significantly alters expression of NRXN1 and NRXN2 at key phases of development, according to a brief report in the June issue of Molecular Psychiatry.
A large population survey in England finds many adults with undiagnosed autism, bringing the disorder’s prevalence in adults to 1 in 100, approximately the same rate as in children, according to a report in May in the Archives of General Psychiatry.
The placenta regulates the levels of the neurotransmitter serotonin in the brains of mice at a key stage in embryonic development, according to a study published 21 April in Nature. The results suggest that the fetal environment can influence the long-term mental health of children, including whether they later develop autism or schizophrenia.
An innovative academic program in New York City public schools is successfully educating children with high-functioning autism alongside their unaffected peers.