Thomas Südhof has achieved stellar scientific results with a style that colleagues call typically German — sober, meticulous and highly competitive.

Exosomes, the brain’s system for delivering and recycling molecules, can be manipulated to carry therapeutic fragments of RNA or DNA across the blood-brain barrier and into neurons. The ingenious new technique was published 20 March in Nature Biotechnology.

There does not appear to be a single genetic or environmental cause of autism, and given the heterogeneity of symptoms, coming up with a clear yes or no test for autism is challenging. Timothy Roberts argues that imaging and electrophysiology are key in the search for autism biomarkers.

Rare mutations with strong effects play a key role in autism and schizophrenia, according to a study published in February in PLoS Genetics. The study identifies rare harmful mutations in three candidate genes that are more common in individuals with one of the disorders than in controls.

Individuals with autism use more brainpower in regions linked to visual perception, and less in those related to planning thoughts and actions, compared with healthy controls, according to a multi-study analysis published today in Human Brain Mapping.

Clumsiness in children with autism may result from the same genetic mutations that contribute to the disorder, according to a study published in February in the Journal of Autism and Developmental Disorders.

Researchers have mapped the architecture of a brain circuit active during vision in the cerebral cortex — a region involved in memory and planning — they reported 10 March in Nature.

A neurotransmitter called VIPR2, or vasoactive intestinal peptide receptor, is a candidate gene for schizophrenia and, potentially, autism, according to a study published in February in Nature.

An Italian group is investigating the provocative hypothesis that some cases of autism are the result of a viral infection passed from sperm to fetus.

Activity in the mirror neuron system may improve with age in people who have autism, according to a study published in February in Biological Psychiatry. The finding could help resolve contradictory reports on the involvement of mirror neurons in the disorder.