The Brain

Autistic people’s ability to understand another person’s thinking does not diminish with age, as it does for non-autistic people.

A gene-editing treatment shows long-lasting effects in a mouse model of Angelman syndrome, a genetic condition related to autism.

All five participants in a clinical trial of a gene therapy for Angelman syndrome experienced leg weakness, leading sponsors to pause the study.

A tool that relies on video cameras and machine learning can identify mice that have mutations in a top autism gene by their behaviors. It also detects how a widely used autism drug affects their movements.

An analysis of four molecular datasets shows a distinct signature, including changes in gene expression and chemical DNA modifications, in some autism brains.

Autistic people have distinct patterns of brain development, which sometimes result in differences in brain structure. Here’s what we know about those differences.

Neurons derived from people with 22q11.2 deletion syndrome show deficits in calcium signaling and electrical activity, pointing to possible therapeutic targets.

The repetitive behaviors seen in autism may originate in the striatum, a cluster of neurons involved with initiating and executing movements.