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Spectrum: Autism Research News

TOPIC

Genes

Rare or common, inherited or spontaneous, mutations form the core of autism risk.

November 2018
Illustration shows Austria lagging behind Germany--doctors and researchers are taking bigger steps in Germany.

How Austria can restore its status as a center of autism research

by  /  6 November 2018

Austria must train more autism specialists, expand its research funding and build more centers for autism diagnosis and treatment.

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Neurons glow green in mice brain.

Loss of autism gene alters landscape of inhibitory brain signals

by  /  6 November 2018

Mice lacking one copy of a leading autism gene have hyperexcitable brains and problems with learning and memory.

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Roundworm roundup may reveal function of autism genes

by  /  6 November 2018

Tracking how roundworms crawl has enabled scientists to determine that many autism genes are involved in sensory processing and learning.

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Rett marmoset model made with CRISPR has its debut

by  /  5 November 2018

Scientists used the gene-editing tool CRISPR to create two marmosets lacking MECP2, the gene mutated in Rett syndrome.

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Tiny lad mouse on a gloved hand.

New mouse model shows brain effects of autism gene

by  /  4 November 2018

Mice lacking one copy of a gene linked to autism are small and show striking changes in the number and quality of their cries.

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October 2018

Massive sequencing project identifies new genetic syndromes

by  /  23 October 2018

The largest-ever set of sequences from people with developmental delay has revealed 43 new genetic diagnoses.

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Brain cells under magnification glow red, purple and blue.

Mini-brains may pin down key genes in large mutations

by  /  22 October 2018

Clusters of brain cells — so-called ‘mini-brains’ grown in the lab — may help researchers understand how large stretches of duplicated or deleted DNA affect the brain.

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A digital drawing shows two groups of people forming large arrows, see from above.

Mutation types tied to autism converge on shared set of genes

by  /  18 October 2018

Genes linked to autism in sequencing studies tend be located in long stretches of DNA that are duplicated or missing in some people with developmental conditions.

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A boy toddler learns to walk with an adult holding his hands.

Some ‘autism genes’ show stronger ties to related conditions

by  /  17 October 2018

The largest autism sequencing study to date implicates 99 genes in the condition — but nearly half have a tighter link to intellectual disability or developmental delay.

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An illustration shows a mosaic-like view of viruses delivering genes to the brain.

Angelman syndrome: Bellwether for genetic therapy in autism

by ,  /  16 October 2018

It is not a matter of whether there will be clinical trials of genetic therapy for Angelman syndrome, but when.

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