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Spectrum: Autism Research News

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Genes

Rare or common, inherited or spontaneous, mutations form the core of autism risk.

October 2019

Brain ‘organoids’ point to new drug target for fragile X syndrome

by  /  18 October 2019

New findings hint at why drugs that work in mouse models of fragile X syndrome have not been effective in people.

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Single molecule tracks with mutation’s path to autism, cancer

by  /  17 October 2019

A molecule made by mitochondria, the energy factories of cells, might help doctors forecast the impact of mutations in a top autism gene.

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Massive project doubles list of genes tied to autism

by  /  17 October 2019

The largest analysis of sequences from autistic people and their families implicates 184 genes in the condition — nearly doubling the previous estimate.

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black and blue striped dress on pregnant woman shows DNA helix

Rare access to fetal tissue yields valuable insights into autism

by  /  15 October 2019

Molecular biologist Jonathan Mill is probing gene expression’s role in autism in uncharted territory — the fetal human brain.

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Study finds unexpected role for top autism gene

by  /  14 October 2019

SETD5, a leading candidate for autism risk, may control thousands of genes by modifying a protein involved in packaging DNA.

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White rice in cage

Testing gene therapy for autism in mice? Consider your controls

by  /  3 October 2019

Deleting the mutation from an autism gene may reverse some autism traits in mice, according to a new study. But the results may be a fluke.

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September 2019

Genetic registry reaps bounty of new autism genes

by  /  30 September 2019

An analysis of genetic sequences from nearly 500 people with autism and their relatives has linked 13 new genes to the condition. It has also uncovered a genetic cause for autism in about 10 percent of the autistic participants.

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X chromosome with lots of contrasty texture inside, transparent outside

Genome structure unlikely to wield major influence on gene expression

by  /  27 September 2019

New findings call into question a fundamental assumption about how genes are regulated.

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row of babies playing with toys that look like genome sequence

Studies of tuberous sclerosis may shed light on biology of autism

by  /  24 September 2019

Tuberous sclerosis provides a unique opportunity to understand autism because about half of people with that single-gene condition also have autism.

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colorful clusters of cells

Atlas of developing brain reveals rainbow of cell types

by  /  20 September 2019

An online resource reveals all major cell types in the developing human brain during the period in which autism is thought to arise.

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