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Spectrum: Autism Research News

Tag: SNPs

September 2010

X-linked gene increases autism risk in boys

by  /  16 September 2010

A newly characterized gene on the X chromosome may be disrupted in up to one percent of people with autism, researchers reported Wednesday in Science Translational Medicine.

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August 2010

Power shortage

by  /  5 August 2010

One of the largest genome-wide association studies for autism spectrum disorders, reported last week in Human Molecular Genetics, allows only one definitive conclusion: it isn’t large enough.

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June 2010

Autism marked by copy number changes in coding regions

by  /  11 June 2010

People with autism harbor more copy number variants (CNVs) — deletions or duplications of large chunks of DNA — compared with controls, but only in the protein-coding regions of the genome, researchers reported Wednesday in Nature. The study also pinpointed more than 100 new risk genes for autism.

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May 2010

Study implicates cell-adhesion proteins in autism

by  /  18 May 2010

Variations in two genes needed to form connections between brain cells may be associated with autism spectrum disorder, according to a study published 25 March in Molecular Autism. Some variants in the genes seem to increase susceptibility to autism, whereas others protect children from developing the disorder.

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Mouse models reveal workings of neuroligin-1

by  /  4 May 2010

Researchers are tinkering with mouse models to investigate the function of a protein that helps wire neurons together and that has repeatedly been linked to autism. Three such reports of the protein, neuroligin-1, have appeared this year.

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April 2010

Future of autism genetics is all in the family

by  /  30 April 2010

Two independent teams have identified the genetic culprits of three rare, inherited diseases by sequencing the genomes of several members of the same family. As the cost of whole-genome sequencing plummets, this family-based approach will reveal candidate genes not just for rare diseases but for common, complex disorders such as autism, experts say.

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Undressing oxytocin

by  /  29 April 2010

Scientists have been unable to replicate work showing an association between oxytocin receptor genes and autism.

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Researchers probe genetic overlap between ADHD, autism

by  /  22 April 2010

Attention deficit hyperactivity disorder (ADHD) and autism may have more in common than childhood onset and a few similar symptoms. New research suggests the conditions share genetic roots.

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March 2010

Evan Eichler: Following his instincts to autism ‘hotspots’

by  /  22 March 2010

With an openness to collaboration and a healthy dose of daring, Evan Eichler has turned his offbeat interest in repeat DNA sequences into a new understanding of how genomes evolve, expediting the search for genes disrupted in autism.

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Clinical, animal studies probe DISC1’s role in autism

by  /  1 March 2010

Several genetic and animal studies in the past year have found intriguing ties between autism and DISC1, one of the oldest candidate genes for psychiatric disorders.

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