Skip to main content

Spectrum: Autism Research News

Tag: SNPs

July 2011

Clinical research: Antidepressant use in pregnancy linked to autism

by  /  22 July 2011

Taking antidepressants while pregnant may slightly increase the risk of having a child with autism, reports a study published 4 July in the Archives of General Psychiatry.

Comments

Clinical research: Blood test could recommend drug treatment

by  /  13 July 2011

Children who express a subset of genes — including one located in the autism-associated chromosomal region 16p11.2 — at higher or lower levels than normal benefit from treatment with the antipsychotic drug risperidone, according to a study published 7 June in the Pharmacogenomics Journal.

Comments

Computer algorithm boosts power of sequencing studies

by  /  13 July 2011

A new computer algorithm has identified the gene responsible for a newly discovered human disease, researchers report this week in The American Journal of Human Genetics. Unlike traditional methods, the algorithm takes into account both the odds of a particular genetic variant being associated with the disorder and the variant’s effect on protein function.

Comments
June 2011

Clinical research: Prenatal vitamins lower risk of autism

by  /  24 June 2011

Taking prenatal vitamins for three months before conception and four weeks after could lower the risk of having a child with autism, particularly for women who carry certain genetic variants, according to a study published in the July issue of Epidemiology.

Comments

Molecular mechanisms: SHANK3 mutants function at synapse

by  /  22 June 2011

Spontaneous and inherited mutations in SHANK3 both inhibit the protein’s role at synapses, the junctions between neurons, according to a study published 24 May in Molecular Psychiatry.

Comments

Database reveals lineage of laboratory mouse strains

by  /  15 June 2011

A new online database that compiles genomic sequence information for 162 mouse strains shows that classical laboratory strains have limited genetic diversity, according to a report published 29 May in Nature Genetics.

Comments

Molecular mechanisms: Mouse model supports role for SHANK3 in autism

by  /  3 June 2011

Mice with a mutation in SHANK3, a leading autism candidate gene, show moderate social defects, including less-than-normal interest in other mice. The findings, published 27 May in Cell, suggest that mutations in different sites on the gene can lead to different behaviors. This paper was retracted on 17 January 2013. Associate director of research Alan Packer discusses the implications of the retraction here.

Comments
May 2011

Genetics: Multiple hits affect key pathways in autism

by  /  24 May 2011

Individuals with autism have multiple mutations in a pathway that functions in the mitochondria, the energy center of the cell, according to a study published 27 April in the European Journal of Human Genetics. They also have higher-than-average numbers of variants in pathways involved in metabolism, gene expression and the regulation of cell division.

Comments

Family sequencing study boosts two-hit model of autism

by  /  15 May 2011

A new analysis of children with autism and their unaffected parents provides the best evidence to date that mutations in multiple genes may work together to cause autism and related disorders.

Comments

Genetics: Metabolism gene trio linked to autism

by  /  13 May 2011

Variants of three genes involved in a metabolic pathway together raise the risk of autism, according to a study published 5 March in the Journal of Neurodevelopmental Disorders.

Comments