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Society for Neuroscience 2019

SFN 2019
Coloured transmission electron micrograph (TEM) showing several unmyelinated (green) and myelinated (green with blue border) axons. Schwann cell cytoplasm is red and a nucleus (bottom left) is yellow. The pink lines are the basement membranes.

Loss of insulation on neurons may contribute to autism

by  /  6 March 2020
Genes involved in the formation of myelin, a fatty substance that sheathes neurons, are altered in autistic people and in several mouse models.
SFN 2019

In brain imaging studies of autism, location may alter results

by  /  27 January 2020
A new analysis hints at the source of the rampant inconsistency among brain imaging studies in autism: significant differences among study sites.
SFN 2019
Micrograph of brain organoid in green and red

Spheres of brain cells may offer crystal ball for autism’s origins

by  /  24 January 2020
Researchers have monitored the active genome in brain organoids over the course of nearly two years — and may find clues to autism’s roots.
January 2020
Small child with fever has his temperature checked
SFN 2019

Fever’s immune effect on brain may ease autism traits

by  /  8 January 2020

An immune molecule produced during a fever improves sociability in three mouse models of autism.

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October 2019
Nightime view of the skyline of downtown Chicago
SFN 2019

Takeaways from SfN 2019

by  /  24 October 2019

Thousands of research presentations, five days: Spectrum looks back at the 2019 Society for Neuroscience annual meeting in Chicago.

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Group of 6 brains show sections colored differently
SFN 2019

Brain scans from one person build reliable map of brain activity

by  /  24 October 2019

Mapping brain activity in one person doing multiple tasks creates a more accurate picture of the brain than averaging the brain activity of multiple people doing a single task.

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micrographs of brain areas in red.
SFN 2019

Drug counteracts effects of doubled autism gene

by  /  24 October 2019

An experimental drug tamps down the expression of a gene duplicated in an autism-related condition and restores typical behavior in mice.

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white mouse
SFN 2019

Double immune hit challenges female mice’s resistance to autism

by  /  23 October 2019

Female mice can withstand a maternal antibody that triggers brain abnormalities and autism-like behaviors in males. But additional immune challenges spell trouble.

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Neurons in a fish glow green.
SFN 2019

Erasable sensor of brain activity could reveal roots of social behavior

by  /  23 October 2019

Researchers unveiled a reversible new technique for labeling active neurons in freely moving animals.

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Two pairs of neurons shown in red.
SFN 2019

Gene editing rids mice of DNA segment linked to autism

by  /  23 October 2019

Researchers have used a new gene-editing technique to delete a segment of DNA associated with autism and schizophrenia from mouse brain cells.

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SFN 2019

Gene-edited marmosets may mimic Rett syndrome traits

by  /  23 October 2019

Researchers have used the gene-editing tool CRISPR to disable the MECP2 gene in marmoset embryos. The six such marmosets created seem to recapitulate aspects of Rett syndrome.

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human cell
SFN 2019

In-cell sequencing reveals genome’s natural geometry

by  /  23 October 2019

Researchers have developed a method for sequencing the genome of an intact single cell, revealing its spatial arrangement within the nucleus.

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Mitochondrion, coloured transmission electron micrograph (TEM). Mitochondria are a type of organelle found in the cytoplasm of eukaryotic cells. They oxidise sugars and fats to produce energy in a process called respiration. A mitochondrion has two membranes, a smooth outer membrane and a folded inner membrane. The folds of the inner membrane are called cristae, and it is here that the chemical reactions to produce energy take place. Magnification: x62,800 when printed at 10 centimetres wide.
SFN 2019

Leaky mitochondria may play central role in fragile X syndrome

by  /  23 October 2019

Some traits of fragile X syndrome may be due to problems with mitochondria, the cell’s energy factories.

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