Preliminary results from a placebo-controlled trial of the antibiotic minocycline in children with fragile X syndrome suggest the drug alleviates some aspects of the disorder, according to research presented Friday at the International Meeting for Autism Research in Toronto.

By creating genetically engineered fish, two independent groups have identified genes in an autism hotspot on chromosome 16 that influence head size and brain development. 

Combining functional magnetic resonance imaging of rat brains with a technique that uses light to detect neuronal activity can help researchers hone in on the source of the activity, according to a study published 6 May in Nature Methods.

Mice lacking the autism-associated gene SHANK2 show autism-like behaviors similar to those seen in mice lacking SHANK3, another member of the same gene family. But SHANK2 and SHANK3 mice have distinct alterations at neuronal junctions, according to a report published 29 April in Nature.

A pilot project highlights how adult stem cells could be used to test and select personalized therapies.

The bundles of nerve fibers that connect two regions important for language are abnormal in the brains of children with autism, according to a study published 5 April in the American Journal of Neuroradiology.

Researchers have identified deletions in SHANK1 — the third member of a gene family that is closely linked to autism — in five men with the disorder, they reported 4 May in the American Journal of Human Genetics. This is the first study linking SHANK1 mutations to people with autism.

Propranolol, a drug used to treat heart disease and anxiety, might improve memory and attention deficits in autism, according to a study published in the May issue of the Journal of the International Neuropsychological Society.

Identifying genetic and other factors that protect children at risk of autism from developing the disorder could provide new avenues for treatment.

The brains of individuals with autism have higher-than-typical levels of the precursor to a neuronal growth factor called BDNF, according to a study published in the April issue of the Journal of Neuropathology and Experimental Neurology. The results suggest a mechanism for altered brain development in autism.