Skip to main content

TOPIC

Genes

Rare or common, inherited or spontaneous, mutations form the core of autism risk.

November 2018
Neurons glow green in mice brain.
News

Loss of autism gene alters landscape of inhibitory brain signals

by  /  6 November 2018

Mice lacking one copy of a leading autism gene have hyperexcitable brains and problems with learning and memory.

0 Comments
News

Roundworm roundup may reveal function of autism genes

by  /  6 November 2018

Tracking how roundworms crawl has enabled scientists to determine that many autism genes are involved in sensory processing and learning.

0 Comments
News

Rett marmoset model made with CRISPR has its debut

by  /  5 November 2018

Scientists used the gene-editing tool CRISPR to create two marmosets lacking MECP2, the gene mutated in Rett syndrome.

0 Comments
Tiny lad mouse on a gloved hand.
News

New mouse model shows brain effects of autism gene

by  /  4 November 2018

Mice lacking one copy of a gene linked to autism are small and show striking changes in the number and quality of their cries.

0 Comments
October 2018
News

Massive sequencing project identifies new genetic syndromes

by  /  23 October 2018

The largest-ever set of sequences from people with developmental delay has revealed 43 new genetic diagnoses.

0 Comments
Brain cells under magnification glow red, purple and blue.
News

Mini-brains may pin down key genes in large mutations

by  /  22 October 2018

Clusters of brain cells — so-called ‘mini-brains’ grown in the lab — may help researchers understand how large stretches of duplicated or deleted DNA affect the brain.

0 Comments
A digital drawing shows two groups of people forming large arrows, see from above.
News

Mutation types tied to autism converge on shared set of genes

by  /  18 October 2018

Genes linked to autism in sequencing studies tend be located in long stretches of DNA that are duplicated or missing in some people with developmental conditions.

0 Comments
A boy toddler learns to walk with an adult holding his hands.
News

Some ‘autism genes’ show stronger ties to related conditions

by  /  17 October 2018

The largest autism sequencing study to date implicates 99 genes in the condition — but nearly half have a tighter link to intellectual disability or developmental delay.

0 Comments
An illustration shows a mosaic-like view of viruses delivering genes to the brain.
Opinion / Viewpoint

Angelman syndrome: Bellwether for genetic therapy in autism

by ,  /  16 October 2018

It is not a matter of whether there will be clinical trials of genetic therapy for Angelman syndrome, but when.

0 Comments
Two children picking mushrooms in a field.
News

Genetics plays outsized role in autism, large study shows

by  /  15 October 2018

Autism is more heritable than anorexia, alcohol dependence, depression and obsessive-compulsive disorder, according to an analysis of data from nearly 4.5 million people.

0 Comments