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Genes

Rare or common, inherited or spontaneous, mutations form the core of autism risk.

October 2019
DNA
News

Rapid assay flags autism mutations in regions that flank genes

by  /  21 October 2019

Researchers have identified mutations within regulatory regions that are likely to contribute to autism, using a speedy system of DNA ‘barcodes.’

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News

Maternal infection may accelerate expression of autism genes

by  /  21 October 2019

Exposure to infection in utero may speed up the expression of many genes linked to autism — and hasten changes in brain anatomy.

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News

Unusual gait marks mice with mutations related to autism

by  /  20 October 2019

Mouse models of two genetic conditions related to autism show abnormalities in their movement patterns.

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News

Transplanted neurons rescue social behavior but not brain circuits

by  /  20 October 2019

Injecting cells called interneurons into the brains of a mouse model of autism restores typical social behavior. But the reason for this effect is a puzzle.

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News

CRISPR therapy may reverse autism mutation’s effects well past infancy

by  /  20 October 2019

Injecting the gene-editing tool CRISPR into the brains of mice may reverse the effects of an autism mutation at any age.

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News

Breaks in long genes may underpin some forms of autism

by  /  20 October 2019

Neurons derived from autistic people with enlarged brains show extensive damage to long genes.

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News

Signaling imbalance in mutant mice supports key autism theory

by  /  19 October 2019

Mice missing a copy of CHD8, a top autism gene, show a signaling imbalance in their brains — a finding in line with a popular hypothesis about autism’s origins.

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Strand of DNA with one base letter highlighted.
News / Toolbox

DNA technique documents key events in cell history

by  /  18 October 2019

A new method uses mutations in DNA to maintain a detailed record of series of cellular events.

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News

Brain ‘organoids’ point to new drug target for fragile X syndrome

by  /  18 October 2019

New findings hint at why drugs that work in mouse models of fragile X syndrome have not been effective in people.

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News

Single molecule tracks with mutation’s path to autism, cancer

by  /  17 October 2019

A molecule made by mitochondria, the energy factories of cells, might help doctors forecast the impact of mutations in a top autism gene.

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