A genetic therapy and an existing drug both restore typical brain size in mice missing DYRK1A, a top autism candidate gene, in the cerebral cortex, a new study shows. The animals typically have smaller brains than controls.
Spectrum: Autism Research News
Rare or common, inherited or spontaneous, mutations form the core of autism risk.
A technique that expands tissue before spotting and sequencing RNA — the molecular messenger for DNA — enables researchers to see where particular genes are expressed in cells.
Deleting the autism-linked gene CHD8 from specific cells in the cerebellum, a brain region important for movement, leads to motor deficits but does not alter social behaviors in mice.
The technique enables researchers to sequence the DNA of an intact cell, providing a unique view of the genome’s organization inside the nucleus.
Mutations in CUL3, a gene strongly linked to autism, may cause differences in brain structure by disrupting cytoskeleton proteins, according to a new study.
Fruit flies with low expression of a gene linked to neurodevelopment have disrupted sleep, poor memory and altered social behavior.
On 20 September 2017, Hurricane Maria passed over Puerto Rico’s Cayo Santiago Island, home to more than 1,500 non-native rhesus macaques. After the storm, the monkeys formed new, unexpected relationships in ways that could offer clues about autism.
Mice missing a copy of chromosomal region 16p11.2 are slow to learn motor tasks and have dysfunction in a brain circuit associated with stress and movement, according to a new study. Normalizing this circuit’s activity corrects the learning deficit.
Genes influence how autistic people react to sights, sounds and other sensory cues, whereas environmental factors shape their tendency to notice and seek out such stimuli, a new study in twins suggests.
An expanding collection of websites compiles up-to-date information on the characteristics of people with mutations in genes linked to autism and other conditions.