Together, the neurons are part of the corticostriatal circuit, which has been implicated in autism.
Spectrum: Autism Research News
The open-source device achieves subcellular resolution in a larger tissue volume than was possible with prior miniscopes, without impinging upon a mouse’s behavior.
The neurons, which have low levels of the gene ASH1L, sprout more branches after the treatment.
The new method, called sonogenetics, noninvasively manipulates neural circuits in mice.
Excitatory and inhibitory neurons can derive from the same cellular source in the developing human brain, a new study suggests, overturning a 20-year-old hypothesis. Tomasz Nowakowski discusses the finding’s implications for autism research.
Deleting a copy of the gene TBX1 depletes the fatty myelin insulation that surrounds neurons and reduces cognitive speed in mice.
The new technique can record hundreds of thousands of neurons firing nearly simultaneously across big swaths of brain tissue in living mice.
The X chromosome holds stronger-than-expected genetic sway over the structure of several brain regions. The genes that may underlie this oversized influence have ties to autism.