Brain imaging do-over offers clues to field’s replication problem
Methodological choices and study-site artifacts confounded an attempt to replicate findings in support of an autism brain-imaging biomarker, according to new unpublished work.
Methodological choices and study-site artifacts confounded an attempt to replicate findings in support of an autism brain-imaging biomarker, according to new unpublished work.
FMR1 loss impairs sodium channels, hindering mouse neurons from generating the electrical signals needed to transmit information.
Many autism-linked genes are somehow tied to cilia, the tiny hair-like sensors that stud a cell’s surface. But the question remains whether, and how, cilia differences contribute to the condition.
The function of microglia and astrocytes in the brain may mediate the intersection of sex-differential biology and autism biology.
Brain cell clusters serve as drug screens and reveal connectivity differences for autism-linked conditions, two new models show.
The transplanted cells integrate into living animals’ neural circuitry and influence behavior.
The machine-learning approach could help identify how brain structure differs between autistic and non-autistic infants, the researchers say.
A well-studied brain response to sound appears earlier than usual in young children with autism.
Many brain regions develop differently between people with 22q11.2 duplications and deletions, and those trajectories also vary with a person’s diagnosis.
What these genes do and how they affect autism depends on when in development they’re studied, despite what classic ‘gene ontology’ analyses say.