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Spectrum: Autism Research News

Tag: cortex

August 2022

Of mice and human interneurons: A Q&A with Moritz Helmstaedter

by  /  1 August 2022

People’s brains have a larger network of inhibitory interneurons than mouse brains do, according to a new study. Changes to that network could contribute to autism or other conditions, says lead investigator Moritz Helmstaedter.

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June 2022
Two young children play with a tablet computer underneath a blanket fort

Brain’s early visual areas reflect autism’s heritability

by  /  16 June 2022

Inherited genetic factors for autism influence brain development, new studies of autistic children and their younger siblings reveal.

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May 2022

Structural brain changes foretell language skills in autistic infants

by ,  /  19 May 2022

Increased white-matter maturation tracks with stronger language abilities later in childhood, but the relationship with cortical thickness is less clear.

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Organoids hint at origins of enlarged brains in autistic people

by  /  13 May 2022

The size of the cerebral cortex seems to depend on when neural progenitor cells multiply or differentiate into glial cells and neurons.

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MRIs

Growth charts map brain changes across lifespan

by  /  12 May 2022

The new resource is the first to chart human brain development from before birth to 100 years of age.

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Color-coded brain images showing reduced thickness of superior frontal gyrus and other regions associated with presence of increased levels of inflammatory moleucle IL-6.

Inflammation may reshape brain regions tied to autism

by  /  6 May 2022

Having a genetic predisposition to inflammation is linked to structural changes in brain regions implicated in neurodevelopmental conditions.

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3D rendering of a mouse brain showing axons coming from the prefrontal cortex in various colors.

New atlas maps neuronal wiring in mouse brain

by  /  3 May 2022

The ‘projectome’ charts axonal pathways between individual cells in the prefrontal cortex, a brain region implicated in autism.

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April 2022
Micrographs comparing mouse striatal neurons missing TSHZ3 and wildtype striatal neurons.

Two groups of neurons govern autism-like traits in model mice

by  /  15 April 2022

Together, the neurons are part of the corticostriatal circuit, which has been implicated in autism.

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Miniature microscope records thousands of neurons in moving mice

by  /  12 April 2022

The open-source device achieves subcellular resolution in a larger tissue volume than was possible with prior miniscopes, without impinging upon a mouse’s behavior.

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March 2022
Neurons with low levels of ASH1L have fewer and shorter projections

Drug boosts growth of neurons deficient in autism-linked protein

by  /  25 March 2022

The neurons, which have low levels of the gene ASH1L, sprout more branches after the treatment.

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