A transplant of inhibitory neurons during the second week of life prevents social difficulties and a brain signaling imbalance in mice missing a copy of FOXG1.
Spectrum: Autism Research News
A genetic therapy and an existing drug both restore typical brain size in mice missing DYRK1A, a top autism candidate gene, in the cerebral cortex, a new study shows. The animals typically have smaller brains than controls.
Differences in myelin, the insulation that surrounds neuronal projections, may shade measurements of cortical thickness on brain scans, a new study suggests.
Mutations in CUL3, a gene strongly linked to autism, may cause differences in brain structure by disrupting cytoskeleton proteins, according to a new study.
A new atlas profiles gene activity early on during development in the human fetal brain.
Mutations in CHD8 lead to brain overgrowth or undergrowth in mice, depending on how they affect the gene’s expression.
Misaligned gene expression maps suggest that some autism-linked genes play distinct roles in mouse and human brains.
Merging 3D clusters of neurons that mimic different brain regions models the atypical electrical activity seen in an autism-related condition.
An analysis of four molecular datasets shows a distinct signature, including changes in gene expression and chemical DNA modifications, in some autism brains.