A genetic therapy and an existing drug both restore typical brain size in mice missing DYRK1A, a top autism candidate gene, in the cerebral cortex, a new study shows. The animals typically have smaller brains than controls.
Spectrum: Autism Research News
Tag: brain size
Deleting the autism-linked gene CHD8 from specific cells in the cerebellum, a brain region important for movement, leads to motor deficits but does not alter social behaviors in mice.
Mutations in autism-linked genes lead to a variety of changes in brain activity, sensory perception and sleep-wake cycles in zebrafish.
A screening technique tests how inactivated genes affect spheres of cultured brain cells; it could shed light on autism-linked mutations.
The brainstem controls such disparate functions as breathing, sensation and sleep — all of which can be altered in autism.
Brain structure of autistic people with deletions in the chromosomal region 22q11.2 differs from that of autistic people without the deletions.
Children with autism are more likely than typical children to have had problems falling asleep as infants, and to have shown brain overgrowth.
Several regions in the outer layer of the brain are thicker in children and young adults with autism than in their typical peers.