Skip to main content

Tag: X chromosome

December 2020
Brain images color-coded to show structural changes in autism.
News

Gene expression maps reveal origins of brain changes from autism mutations

by  /  4 December 2020

A new study pinpoints the genes and cell types that may underlie the atypical brain structure seen in people with genetic conditions linked to autism.

0 Comments
October 2020
Ralf Schmid, the research director in Neurodevelopmental diseases at the Gene Therapy Program Orphan Disease Center, loads replicated mouse dna into wells in the gel before applying electric current to test the viability of the dna.
Features / Deep Dive

A quest for Quincy: Gene therapies come of age for some forms of autism

by ,  /  14 October 2020

A gene therapy for Angelman syndrome stands at the forefront of efforts to treat autism-linked conditions that stem from single genes.

0 Comments
January 2019
News / Toolbox

Method unravels Rett mutation’s effects on specific brain cells

by  /  11 January 2019

A new technique may reveal how mutations on the X chromosome alter various types of cells in the brain.

0 Comments
September 2018
News / Toolbox

New mouse model paves way for Rett syndrome treatments

by  /  7 September 2018

A new line of female mice may enable researchers to test gene-based therapies for Rett syndrome.

0 Comments
March 2018
Deleting DNA repeats from fragile X neurons restores expression (right, red) of the gene silenced in the syndrome.
News

CRISPR tweak fixes genetic flaw in fragile X syndrome

by  /  29 March 2018

A modified version of the genetic engineering tool CRISPR may restore expression of the gene mutated in fragile X syndrome.

0 Comments
October 2017
Brain scans of boys with fragile X syndrome fall into distinct groupings.
News

Brain scans reveal subtypes of fragile X syndrome in boys

by  /  30 October 2017

Differences in brain structure may distinguish boys with relatively mild features of fragile X syndrome from those with a severe form of the condition.

0 Comments
Microscope image of neuronal injections in brain.
News

Two drugs ease features of autism syndromes in mice

by  /  11 October 2017

Drugs that block certain brain enzymes could help treat two conditions associated with autism.

1 Comment
Week of OctoberOct
2nd
2017
News / Spotted

Cannabis candidate; omega add-on; oxytocin control and more

by  /  6 October 2017

A cannabis gel may ease features of fragile X syndrome, omega fatty acids show promise for autism in two trials, and oxytocin reinforces social behaviors through the brain’s reward pathway.

0 Comments
August 2017
Week of JulyJul
31st
2017
News / Spotted

Autism unsurprised; diagnostic camouflage; Neanderthal legacy and more

by  /  4 August 2017

People with autism aren’t easily surprised, the social camouflage some girls and women with autism use may preclude diagnosis, and autism-related genes are rooted deep in human ancestry.

0 Comments
March 2017
News

Muting X chromosome silencers may serve as remedy for Rett

by  /  30 March 2017

Manipulating pathways that help silence the X chromosome may help treat Rett syndrome, a condition closely related to autism.

0 Comments