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Spectrum: Autism Research News

Tag: X chromosome

August 2012

Molecular mechanisms: Rett protein loss shrinks adult brains

by  /  17 August 2012

Deleting the Rett syndrome gene from mature mouse brains leads to the same neurological and behavioral symptoms as deleting it during a key developmental stage, according to a study published 18 July in the Journal of Neuroscience.

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May 2012

Defects in carnitine metabolism may underlie autism

by  /  10 May 2012

A genetic defect in the synthesis of carnitine, a molecule that is essential for proper mitochondrial function, might slightly increase risk for autism in some children, according to research published 8 May in the Proceedings of the National Academy of Sciences.

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April 2012

Why oh Y

by  /  24 April 2012

New research on children with extra sex chromosomes points to the Y chromosome’s role in autism.

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Noncoding gene linked to autism

by  /  9 April 2012

Researchers have identified a noncoding RNA, a genetic message that is not translated into a protein, that may be involved in autism. The discovery, published 4 April in Science Translational Medicine, came from examining a region on chromosome 5 that has been previously linked to the disorder.

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February 2012

Cognition and behavior: Contaminant acts with autism gene

by  /  28 February 2012

A commonly used flame retardant may lead to deficits in sociability, learning and memory in healthy female mice and those that model Rett syndrome, according to a study published 15 February in Human Molecular Genetics. The effects are different in Rett syndrome models compared with healthy mice, suggesting gene-environment interactions.

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Clinical research: Mice model Rett syndrome’s heart symptoms

by  /  10 February 2012

Mice engineered to carry a Rett syndrome mutation only in neurons are prone to an irregular heartbeat that can lead to sudden death, according to a study published 14 December in Science Translational Medicine.

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Genetics: X chromosome disorder linked to autism

by  /  7 February 2012

Duplication of a region on the X chromosome leads to a genetic disorder characterized by severe autism, according to a study published 25 November in Annals of Neurology.

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January 2012

Genetics: X chromosome gene linked to autism in males

by  /  18 January 2012

TBL1X, a gene located on the X chromosome, is associated with autism in males but not in females, according to a study published 3 November in Molecular Autism.

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A family on a walk.

Clinical research: Autism threshold higher in girls than boys

by  /  11 January 2012

Girls may have a higher threshold for the genetic abnormalities that lead to autism than boys do, according to a new study in the January issue of the American Journal of Medical Genetics Part B.  

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Brain atlas maps gene expression across development

by  /  4 January 2012

Researchers have charted the expression of more than 15,000 brain genes across 15 stages of development, spanning from 4 weeks post-conception to more than 60 years of age, they reported 27 October in Nature.

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