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Tag: macrocephaly

May 2021
Microglia activity seen in red, green and blue.
News

Autism mutation may cause big brain via ‘don’t eat me’ signals

by  /  17 May 2021

An autism-linked mutation could make the brain grow unusually large by prompting cells to express a chemical signal better known for its connection to cancer.

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March 2021
News

Top autism-linked gene has divergent effects on brain growth in mice

by  /  25 March 2021

Mutations in CHD8 lead to brain overgrowth or undergrowth in mice, depending on how they affect the gene’s expression.

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January 2021
dopamine neurons in mice show up green in an area of the brain associated with social reward.
News

Dopamine neurons may dampen social behavior in mouse model of autism

by  /  12 January 2021

Mice missing a copy of the autism-linked gene PTEN show a reduced preference for social interaction, possibly due to atypically large, overconnected dopamine neurons. Easing the overconnection may alleviate this trait.

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organoids in early stages of development.
News

Organoids show how mutations in top autism gene may lead to brain overgrowth in people

by  /  11 January 2021

The loss of CHD8, a top autism gene, speeds up the production of certain neurons and leads to overgrowth in spheres of cultured brain cells.

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November 2020
MRIs show changes over time
News

Big brain may mark subtype of autism

by  /  27 November 2020

Autistic boys with large brains in early childhood still have large brains in adolescence, challenging the long-standing idea that brain enlargement in autism is temporary.

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July 2020
DNA helix with mutation or deletion
News / Toolbox

Scores forecast effects of mutations in autism gene

by  /  8 July 2020

A new analysis links individual mutations in a gene called PTEN to a person’s odds of having autism, cancer or other conditions.

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April 2020
Illustration shows heads and brains inside at various sizes.
News

Autism’s relationship to head size, explained

by  /  9 April 2020

Some people with autism have an unusually large head. What causes the enlargement? And does it have any bearing on outcome?

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Microscopic view of neurons
News

Mutations in autism gene linked to distinct conditions

by  /  3 April 2020

Individuals with mutations in an autism gene called TRIO may have a range of conditions, including intellectual disability and anomalous head size.

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December 2019
a young girl has her height measured by a woman
News

Top autism gene tied to unusual skull, skeletal growth

by  /  12 December 2019

People with mutations in CHD8, a top autism gene, tend to be tall and have large heads.

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November 2019
News

Mouse study reveals overlooked target for autism therapies

by  /  20 November 2019

Blocking one form of an enzyme implicated in autism eases unusual behaviors and seizures in mice missing a top autism gene.

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