Tag: macrocephaly

July 2014
News

Cluster of symptoms reveals gene’s link to autism subtype

by  /  3 July 2014

CHD8, a gene that regulates the structure of DNA, is the closest thing so far to an ‘autism gene,’ suggests a study published today in Cell. People with mutations in this gene all have the same cluster of symptoms, including autism.

11 Comments
Opinion / Q&A

Questions for Nicholas Katsanis: Fishing for autism genes

by  /  1 July 2014

Cell biologist Nicholas Katsanis explains why zebrafish have been key in studying a chromosomal region linked to autism.

0 Comments
June 2014
Opinion / Viewpoint

How to evaluate new medications for autism

by  /  10 June 2014

There are no available medications for treating autism’s core symptoms, but there are several candidates in clinical trials. Jeremy Veenstra-VanderWeele describes the factors researchers must take into account when developing drugs for the disorder.

7 Comments
May 2014
News

Autism-linked chromosomal region regulates brain size

by  /  16 May 2014

The genes in 16p11.2, the autism-linked region on chromosome 16, may directly affect brain size early in development, according to unpublished research presented Thursday at the 2014 International Meeting for Autism Research in Atlanta.

0 Comments
April 2014
News

Molecular mechanisms: Mutant mice seek out social contact

by  /  29 April 2014

Male mice that carry a specific mutation in the autism-linked PTEN gene have enlarged brains and show heightened interest in other mice, according to a study published 7 February in Human Molecular Genetics.

0 Comments
Only human: People carry 271 copies of a repeated DNA sequence, compared with 30 repeats in monkeys, 4 in dolphins and 1 in mice.
News

Repeats in human DNA may aggravate autism symptoms

by  /  21 April 2014

Certain DNA repeats that increased exponentially during human evolution are directly related to the severity of autism symptoms, according to a preliminary study published 20 March in PLoS Genetics.

0 Comments
Opinion / Viewpoint

The cerebellum’s surprisingly evolved role in autism

by  /  1 April 2014

Thought until recently to only coordinate motor skills, the cerebellum is involved in diverse cognitive functions such as language and social interaction, and may play a role in autism, says Emanuel DiCicco-Bloom.

11 Comments
March 2014
Opinion / Viewpoint

Emerging importance of chromatin in autism risk

by ,  /  18 March 2014

Sequencing studies over the past few years have made a dramatic and unexpected discovery: Many of the mutations in individuals with autism are in genes that regulate chromatin, which helps package DNA in the cell nucleus, say Gerald Crabtree and Aryaman Shalizi.

1 Comment
December 2013
Opinion / Viewpoint

Understanding contradictory connectivity reports in autism

by ,  /  10 December 2013

Studies at the level of neural circuits are needed to better understand the importance of both increased and decreased connectivity between different regions in the autism brain, say John Rubenstein and Vikaas Sohal.

1 Comment
November 2013
News

Close look at autism-linked region reveals complex biology

by  /  27 November 2013

Deletion and duplication of the 16p11.2 chromosomal region have opposite effects on brain size, but produce similar alterations in the brain’s processing of sound. Researchers reported these and other unpublished findings at the 2013 Society for Neuroscience annual meeting in San Diego, painting a complex picture of the region’s role in autism.

0 Comments