Researchers have narrowed down a genetic region associated with autism to one protein, cadherin 8, that helps bind cells together, according to a study published online in October in the Journal of Medical Genetics. This is the first time CDH8, the gene that encodes this protein, has been associated with autism.
Spectrum: Autism Research News
Tag: intellectual disability
Loss of activity of FOXP1, a member of a family of genes that regulate gene expression, leads to general behavioral defects, including delays in language, according to a study published in November in The American Journal of Human Genetics.
Individuals with attention deficit hyperactivity disorder (ADHD) have a higher rate of DNA duplications and deletions, including some in regions linked to autism and schizophrenia, according to a study published 23 October in The Lancet.
A common variation within a region on chromosome 16 puts a large proportion of the general population at risk for intellectual disability, according to a study published in August in Nature Genetics.
Changes in diagnostic practices, more active neighborhood networks, and an increase in the number of older parents may all contribute to the massive rates of autism in California, says a group of social scientists. But the numbers still don’t add up.
Autism and intellectual disability often occur together, but in most cases that overlap is not genetic, according to a study of twin pairs published in the American Journal of Medical Genetics. Unraveling this link might help researchers pinpoint brain circuits involved in both conditions, and better understand the diversity of symptoms in the autism spectrum, experts say.
Individuals carrying an extra copy of the genetic region that’s missing in Williams syndrome — which causes mental retardation and a hyper-friendly personality — have language impairments and other autism-like social difficulties, according to a wave of new research on this duplication syndrome.
The mouse brain has more than 1,300 regions for which the copy from one parent is expressed more often than the one from the other parent, according to two studies published today in Science. These so-called imprinted genes have been proposed to cause some cases of autism, but the researchers say their findings do not support that theory.