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Signs & Symptoms

Autism’s core symptoms accompany a constellation of subtle signs that scientists are just beginning to unmask.

November 2008
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Pathways to plasticity

by  /  18 November 2008

The molecular mechanisms underlying synaptic plasticity ― the ability of neurons to change the strength of their connections ― can vary across different inhibitory neural circuits as much as they can vary across excitatory neural circuits, according to research presented this morning at the Society for Neuroscience meeting.

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Lithium’s effect on fragile X mice

by  /  18 November 2008

Lithium treatment reverses some of the behavioral and brain-cell abnormalities in mouse models of fragile X syndrome ― an inherited form of mental retardation that includes learning deficits, aggressiveness, and social withdrawal ― according to research presented today at the Society for Neuroscience meeting.

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Creating stem cells to study autism

by  /  18 November 2008

A team of scientists is reprogramming adult stem cells generated from tiny skin samples of people with autism to form nerve cells, creating a powerful research tool for the disorder.

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Altering epigenetic changes

by  /  17 November 2008

Targeting epigenetic mechanisms may offer potential new therapies for people with developmental disorders including autism, researchers said today at the Society for Neuroscience meeting.

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A simple behavioral test for mice

by  /  17 November 2008

Researchers at the Society for Neuroscience today described a new test for animal behavior that doesn’t interfere with normal mouse behavior, doesn’t require human interaction, and makes it simple to take long-term measurements: the ‘licking testʼ.

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GAP43 mutant mice mimic autism

by  /  17 November 2008

Mice missing a copy of GAP43, a gene involved in the development of axons ― the thin strands that conduct electrical signals between nerve cells ― show biological and behavioral parallels to autism, according to unpublished research presented in a poster session today at the Society for Neuroscience conference.

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Treating Rett syndrome

by  /  17 November 2008

Treatment with the insulin-like growth factor (IGF) greatly improves the health of mouse models of Rett syndrome ― a regressive genetic disorder that causes mental retardation, seizures, and autistic features ― according to unpublished researched presented this morning at the Society for Neuroscience conference.

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Neurogenesis gone wrong

by  /  16 November 2008

Schizophrenia may be a consequence of neuronal birth gone awry, according to unpublished research presented today at the Society for Neuroscience conference.

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Reversing autism-related disorders

by  /  16 November 2008

Research on mouse models published in the past year is paving the way to reversing the symptoms of some autism-related disorders, National Institute Health directors told a packed room of 80 reporters at the morning at the Society for Neuroscience conference.

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A mouse model for autism

by  /  15 November 2008

A mouse model of neurofibromatosis ― a genetic neurodevelopmental disorder that leads to nerve tumors, memory problems and, often, autism ― exhibits deficits in social interaction and social learning, according to research presented in a poster session today at the Society for Neuroscience conference.

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