Tag: SHANK2

June 2019
Video of three mice running on a wheel
News / Toolbox

Mechanical tracker measures social activity of multiple mice for days

by  /  28 June 2019

A new system enables researchers to automatically track the social behavior of up to four mice for days at a time.

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May 2019
grid of lab grown neurons
News / Toolbox

New method creates uniform cultures of lab-grown neurons

by  /  16 May 2019

A new technique leads to neuron cultures of consistent quality, enabling scientists to study how autism mutations alter neurons.

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February 2017
News

Rats with mutant SHANK genes show autism-like behaviors

by  /  16 February 2017

Researchers have engineered two new rats with mutations in a family of genes that function at neuronal junctions, they reported today at the 2014 International Meeting for Autism Research in Atlanta.

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January 2016
News

Neighboring mutations in gene may spawn separate conditions

by  /  25 January 2016

Two seemingly similar mutations in the SHANK3 gene have divergent effects on the brain and behavior.

1 Comment
January 2015
News

Small snippets of genes may have big effects in autism

by  /  22 January 2015

Small pieces of DNA within genes, dubbed ‘microexons,’ are abnormally regulated in people with autism, suggests a study of postmortem brains.

2 Comments
November 2014
News

Family of autism-linked proteins helps neurons communicate

by  /  16 November 2014

The SHANK family of proteins, some of which are strong autism candidates, work together to facilitate brain signaling, according to unpublished results presented yesterday at the 2014 Society for Neuroscience annual meeting in Washington, D.C.

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September 2014
News

SHANK3 mutations turn up in high proportion of autism cases

by  /  18 September 2014

About 2 percent of people who have both autism and intellectual disability carry harmful mutations in SHANK3, a protein that helps organize the connections between neurons, according to a study published 4 September in PLoS Genetics.

1 Comment
March 2014
News

Genetics: MicroRNA may suppress autism gene expression

by  /  25 March 2014

A small fragment of RNA may regulate the expression of RORA, a gene implicated in many autism-related pathways, according to a study published 6 February in Scientific Reports.

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December 2013
News

Drug fixes cellular defects in autism-related disorder

by  /  2 December 2013

A new stem-cell model of Phelan-McDermid syndrome points to a possible treatment for the rare autism-related disorder, according to a study published in Nature.

3 Comments
November 2013
Opinion

Where will the focus on SHANK genes lead?

by  /  11 November 2013

Geneticists react to discoveries and identify next steps for one of autism’s most promising candidate genes.

2 Comments