Tag: SHANK2

November 2013
Opinion / Viewpoint

SHANK mutations converge at neuronal junctions in autism

by ,  /  5 November 2013

SHANK3, one of the strongest candidate genes for autism, has the potential to be a molecular entry point into understanding the synaptic, developmental and circuit origins of the disorder.
 

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October 2013
Opinion / Viewpoint

Robust models

by  /  11 October 2013

Rodent models that recapitulate the core features of autism often have additional traits, leading us to ask whether these traits are integral to autism, says Elisa Hill-Yardin.

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June 2012
News

SHANK2 mouse models show opposite brain signaling

by  /  25 June 2012

Two new strains of mice carrying different mutations in the SHANK2 gene show similar autism-like behaviors but opposing effects on brain signaling, according to two independent studies published 14 June in Nature.

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May 2012
News

Molecular mechanisms: SHANK2, SHANK3 mouse brains differ

by  /  16 May 2012

Mice lacking the autism-associated gene SHANK2 show autism-like behaviors similar to those seen in mice lacking SHANK3, another member of the same gene family. But SHANK2 and SHANK3 mice have distinct alterations at neuronal junctions, according to a report published 29 April in Nature.

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February 2012
News

SHANK2 study bolsters ‘multi-hit’ gene model of autism

by  /  13 February 2012

By screening the genomes of hundreds of people with autism and analyzing the effects of newly identified mutations in cultured neurons, researchers have clarified the disorder’s link to the SHANK2 gene.

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November 2011
News

Researchers debut SHANK2 mouse, SHANK3 rat

by  /  14 November 2011

Mice lacking the autism risk gene SHANK2 show social deficits and are extremely hyperactive, according to unpublished research presented Saturday at the 2011 Society for Neuroscience annual meeting in Washington, D.C.

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July 2010
News

Synaptic defects link autism, schizophrenia

by  /  2 July 2010

Several independent groups have found previously unknown risk genes for autism, schizophrenia and mental retardation. The candidate genes have one thing in common: they encode proteins that are needed for the healthy function of synapses, the junctions between neurons.

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June 2010
News

Autism marked by copy number changes in coding regions

by  /  11 June 2010

People with autism harbor more copy number variants (CNVs) — deletions or duplications of large chunks of DNA — compared with controls, but only in the protein-coding regions of the genome, researchers reported Wednesday in Nature. The study also pinpointed more than 100 new risk genes for autism.

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