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Spectrum: Autism Research News

Tag: rats

December 2015

‘CRISPR’ way to cut genes speeds advances in autism

by  /  14 December 2015

A molecular Swiss army knife for DNA is hewing a path to clarify the subtle effects of thousands of autism-linked mutations.

1 Comment
October 2015

Environmental double hit may induce seizures, autism behaviors

by  /  21 October 2015

The combination of prenatal stress and a preterm labor drug may elicit seizures and autism-like behaviors in rat pups.

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Differences between rodents show limitations of models

by  /  20 October 2015

The same autism-linked mutation can lead to dramatically different behaviors in rats and mice.

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April 2015

Blood pressure drug may protect brain from seizures

by  /  7 April 2015

A blood pressure drug called bumetanide may shield the brain from the effects of severe seizures early in life.

10 Comments
November 2014

Enriched environment staves off autism-like behavior in rats

by  /  20 November 2014

Rats exposed in utero to the epilepsy drug valproic acid, a risk factor for autism, do not develop autism-like behaviors if they are reared in a stimulating environment. Researchers presented the unpublished findings yesterday at the 2014 Society for Neuroscience annual meeting in Washington, D.C.

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Family of autism-linked proteins helps neurons communicate

by  /  16 November 2014

The SHANK family of proteins, some of which are strong autism candidates, work together to facilitate brain signaling, according to unpublished results presented yesterday at the 2014 Society for Neuroscience annual meeting in Washington, D.C.

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September 2014
Mouse lab test: the three chambered assay

Optimizing behavioral assays for mouse models of autism

by  /  23 September 2014

As the number of autism rodent models climbs, it is a good time for the field to step back and consider the best practices for assessing autism-like symptoms in rodents, says Jacqueline Crawley.

3 Comments
June 2014

For autism research, rats may be new top model

by  /  9 June 2014

Two new rat models of autism don’t roughhouse like normal rats do, and show some compulsive behaviors, according to a study published in April in Behavioral Neuroscience. The models underscore the advantage rats have over mice in modeling complex social behaviors. 

6 Comments
March 2014

Come-hither rat cry could measure social interest

by  /  5 March 2014

When navigating a maze, rats move toward happy rodent sounds and away from those signaling alarm, according to a review published 4 February in the Journal of Neuroscience Methods. The method could be used to assay social behavior in rodent models of autism.

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February 2014

Cognition and behavior: Epilepsy drug alters rodent gut

by  /  14 February 2014

In utero exposure to the epilepsy drug valproic acid, which ups the risk of autism, may alter the composition of gut bacteria in rodents, according a study published 11 December in Brain Behavior and Immunity.

2 Comments