In autism research, as in other fields, small sample sizes can lead to false findings. The size of the sample needed for statistical significance depends on the type of study.

Genetic variants across the genome contribute to about 8 percent of the risk for certain developmental conditions — much more than previously thought.

Variants that control gene expression are often involved in whether a mutation ends up being harmful, and how harmful it is.

Software to identify genetic variants, along with a new synthetic human genome, could help scientists discover mutations associated with conditions such as autism.

Watch the complete replay of this journal club, which featured a paper exploring rare genetic variation in psychiatric conditions, including autism.

We must diversify databases of reference DNA to improve our ability to interpret the consequences of genetic variation.

A mouse model based on exposure to an epilepsy drug offers a useful window into the brain circuits altered in autism.

An algorithm combs through genetic data to identify variants involved in autism and four other brain conditions.

Autism and attention deficit hyperactivity disorder often coincide, but the search for common biological roots has turned up conflicting evidence.

This year’s list of top papers highlights nuances in the genetics of autism and new leads on early treatment.