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Spectrum: Autism Research News

Tag: rare variants

October 2015

In search of factors that shield girls against autism

by  /  19 October 2015

Identifying the factors that protect girls from autism may help us understand and possibly treat the disorder.

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New clues connect chemical messenger to autism

by  /  16 October 2015

New evidence implicates the neurotransmitter glycine, which dampens brain signals, in autism.

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August 2015

Control centers for genes rife with autism-linked DNA blips

by  /  3 August 2015

DNA sequences called enhancers — which boost the expression of genes from within or outside them — are enriched for genetic variants linked to autism, suggests a new study. The finding may help researchers understand how variants outside genes contribute to autism.

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May 2015

Facebook, brain games may reveal DNA deletion’s effects

by  /  4 May 2015

Researchers are using social media and an online ‘brain-training’ program to study people with rare chromosomal abnormalities linked to autism.

36 Comments
March 2015

Stunted squeaks signal social deficits in autism model

by  /  5 March 2015

Male mice with a genetic variant linked to autism vocalize less in social situations than controls do during encounters with female mice. The findings help to characterize the effects of variants in the 16p11.2 chromosomal region.

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February 2015

Study downgrades autism gene’s effects to rare glitches

by  /  16 February 2015

After eight years of prominence as an autism risk gene, a new analysis significantly brings down CNTNAP2’s importance in the disorder: According to the study, rare mutations in a single copy of the gene are unlikely to cause autism. 

11 Comments
Week of FebruaryFeb
9th
2015

Spotted: Maladjusted foals; Kanner controversy

by  /  13 February 2015

Some newborn horses have features of autism, and researchers argue over who first described the disorder.

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Some sibling sets arrive at autism with different mutations

by  /  5 February 2015

Less than one-third of sibling pairs with autism who carry rare mutations in autism-linked genes share those mutations, according to the largest study yet to sequence whole genomes of people with the disorder. The study questions the assumption that autism’s risk factors run in families, but some experts are skeptical.

6 Comments
December 2014

Editors’ picks: Our favorite stories from 2014

by  /  22 December 2014

This year was full of big headlines in autism research. But the biggest stories aren’t necessarily the best — here are some gems you may have missed over the year.

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Method predicts impact of DNA variants on gene expression

by  /  18 December 2014

A new computational approach predicts how sequence variations in both the coding and noncoding regions of a gene affect the gene’s expression. The method, described today in Science, may help researchers understand how specific variants contribute to disorders such as autism.

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