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Spectrum: Autism Research News

Tag: PTEN

November 2021
Stylized illustration combines flat color and 3D forms make up a mitochondria with human heads inside it.

Meet the ‘mitomaniacs’ who say mitochondria matter in autism

by  /  22 November 2021

Clues that problems with mitochondria contribute to autism have been accumulating for decades. In the past five years, a mutant mouse and a flurry of findings have energized the field.

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September 2021
Illustration of hybrid objects: part light bulb, part lab vial, some in blue and some in red to signify null and replicated results

Null and Noteworthy: Null rejection, repetitive behaviors, unsuccessful treatments

by  /  23 September 2021

In this edition of Null and Noteworthy, tests of intranasal oxytocin and an Angelman syndrome treatment fail to see results.

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A lighthearted, colorful, chaotic lab scene with fruit flies flying in formation, worms peeking out of piles of dirt and zebrafish spilling out of beakers.

What studying worms, flies and fish says about autism

by  /  8 September 2021

Researchers are increasingly turning to simple animals to learn about autism biology and find leads for new drugs.

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August 2021
Holly Stessman standing in her garden looking up and holding her two chickens.

Beyond the Bench: A conversation with Holly Stessman

by  /  13 August 2021

When Holly Stessman isn’t probing autism genes, she is tending to her flock of chickens or seeking out the next great sci-fi movie.

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July 2021
Micrograph showing fewer neurons in fetal mice whose mothers have only one functional copy of PTEN.

Maternal genetics may contribute to autism-like traits in mice via inflammation

by  /  2 July 2021

A mouse model hints that genes linked to inflammation in some women may increase the likelihood of autism in their children.

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April 2021
Two views of mouse brain slices colorized in green and red.

Jump-starting growth signaling reverses microcephaly in autism mouse model

by  /  29 April 2021

A genetic therapy and an existing drug both restore typical brain size in mice missing DYRK1A, a top autism candidate gene, in the cerebral cortex, a new study shows. The animals typically have smaller brains than controls.

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March 2021
Oligodendrocyte shown orange on black in this scanning electron micrograph.

How oligodendrocytes may shape autism

by  /  15 March 2021

A growing body of evidence shows that brain cells called oligodendrocytes may play a larger role in autism than previously thought.

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February 2021
DNA mutation

Proteins linked to top autism gene might aid early diagnosis

by  /  26 February 2021

Blood levels of PTEN protein and associated molecules could eventually help diagnose autism and other neurological conditions — and predict their outcomes.

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cells in a mouse brain show the mutations in green.

Molecular switch marks mosaic mutations in mice

by  /  11 February 2021

A new tool enables researchers to create mosaic mutations in only some cells and then accurately identify which cells are affected.

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January 2021
dopamine neurons in mice show up green in an area of the brain associated with social reward.

Dopamine neurons may dampen social behavior in mouse model of autism

by  /  12 January 2021

Mice missing a copy of the autism-linked gene PTEN show a reduced preference for social interaction, possibly due to atypically large, overconnected dopamine neurons. Easing the overconnection may alleviate this trait.

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