Loss of one copy of the autism-linked gene PTEN in mouse neurons boosts production of a certain ion channel, and decreases the neurons’ firing rate, according to a study published 21 October in Proceedings of the National Academy of Sciences.
Spectrum: Autism Research News
Elevated levels of EIF4E, which plays a key role in protein synthesis, lead to autism-like behaviors and abnormal neuronal signaling in mice, according to a study published 17 January in Nature.
Children with autism and their unaffected twins have heads that are significantly larger than average, according to a study published 16 January in the Journal of Autism and Developmental Disorders.
FMRP, the protein missing in fragile X syndrome, binds to the RNA sequences of 939 genes, 93 of which have been linked to autism, according to a study published 20 December in Nature.
A new study bolsters the idea that overactive protein synthesis contributes to autism. The findings, published 21 November in Nature, show that dampening a single overabundant protein, neuroligin-1, reverses both abnormal brain activity and social deficits in mice.
A new mouse model provides the first molecular link between the known autism risk gene PTEN and the mitochondrial dysfunction sometimes seen in the disorder. Mice with half the normal amount of PTEN protein in their brains have social deficits reminiscent of autism and faulty mitochondria, according to a study published 10 August in PLoS One.
Knocking out an autism-linked gene called PTEN only in neural stem cells of the hippocampus, a brain region central to learning and memory, throws the development of new neurons off course in adult mice, according to research published last month in the Journal of Neuroscience.
Neurons lacking PTEN, an autism-associated gene also involved in cancer, are hyperconnected to both near and distant brain cells, according to a study published 1 February in The Journal of Neuroscience.
SP1, a protein that regulates the expression of several autism candidate genes, could increase risk of the disorder by simultaneously altering the expression of a number of the genes, according to a study published 24 October in Biological Psychiatry.