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Spectrum: Autism Research News

Tag: PTEN

April 2014

Molecular mechanisms: Mutant mice seek out social contact

by  /  29 April 2014

Male mice that carry a specific mutation in the autism-linked PTEN gene have enlarged brains and show heightened interest in other mice, according to a study published 7 February in Human Molecular Genetics.

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March 2014

Molecular mechanisms: Mild fragile X seen in partial mutants

by  /  4 March 2014

Removing the fragile X syndrome gene from two brain regions in mice leads to signaling defects but does not produce behavioral deficits, according to a study published in the February issue of Autism Research.

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December 2013

Understanding contradictory connectivity reports in autism

by ,  /  10 December 2013

Studies at the level of neural circuits are needed to better understand the importance of both increased and decreased connectivity between different regions in the autism brain, say John Rubenstein and Vikaas Sohal.

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November 2013

Molecular mechanisms: Autism mutation dulls neurons

by  /  19 November 2013

Loss of one copy of the autism-linked gene PTEN in mouse neurons boosts production of a certain ion channel, and decreases the neurons’ firing rate, according to a study published 21 October in Proceedings of the National Academy of Sciences.

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March 2013

Genetics: Head size heterogeneous in autism

by  /  6 March 2013

Children who have autism and large heads may belong to different clinical subsets based on the ratio between their head size and height, according to a study published in the February issue of Autism Research.

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February 2013

Molecular mechanisms: Study links excess protein to autism

by  /  20 February 2013

Elevated levels of EIF4E, which plays a key role in protein synthesis, lead to autism-like behaviors and abnormal neuronal signaling in mice, according to a study published 17 January in Nature.

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Twin study suggests large head size runs in autism families

by  /  14 February 2013

Children with autism and their unaffected twins have heads that are significantly larger than average, according to a study published 16 January in the Journal of Autism and Developmental Disorders.

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January 2013

Hunt for targets of fragile X protein proves perplexing

by  /  31 January 2013

FMRP, the protein missing in fragile X syndrome, binds to the RNA sequences of 939 genes, 93 of which have been linked to autism, according to a study published 20 December in Nature.

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December 2012

Study supports flawed protein synthesis theory of autism

by  /  17 December 2012

A new study bolsters the idea that overactive protein synthesis contributes to autism. The findings, published 21 November in Nature, show that dampening a single overabundant protein, neuroligin-1, reverses both abnormal brain activity and social deficits in mice.

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October 2012

Mouse model links autism risk gene to mitochondria

by  /  11 October 2012

A new mouse model provides the first molecular link between the known autism risk gene PTEN and the mitochondrial dysfunction sometimes seen in the disorder. Mice with half the normal amount of PTEN protein in their brains have social deficits reminiscent of autism and faulty mitochondria, according to a study published 10 August in PLoS One.

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