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Spectrum: Autism Research News

Tag: PTEN

February 2021
DNA mutation

Proteins linked to top autism gene might aid early diagnosis

by  /  26 February 2021

Blood levels of PTEN protein and associated molecules could eventually help diagnose autism and other neurological conditions — and predict their outcomes.

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cells in a mouse brain show the mutations in green.

Molecular switch marks mosaic mutations in mice

by  /  11 February 2021

A new tool enables researchers to create mosaic mutations in only some cells and then accurately identify which cells are affected.

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January 2021
dopamine neurons in mice show up green in an area of the brain associated with social reward.

Dopamine neurons may dampen social behavior in mouse model of autism

by  /  12 January 2021

Mice missing a copy of the autism-linked gene PTEN show a reduced preference for social interaction, possibly due to atypically large, overconnected dopamine neurons. Easing the overconnection may alleviate this trait.

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July 2020
DNA helix with mutation or deletion

Scores forecast effects of mutations in autism gene

by  /  8 July 2020

A new analysis links individual mutations in a gene called PTEN to a person’s odds of having autism, cancer or other conditions.

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May 2020

Extra proteins alter microglia and behavior in mice

by  /  29 May 2020

The overproduction of proteins in brain cells called microglia causes social impairments, cognitive deficits and repetitive behavior in male mice, a new study has found.

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March 2020
microscopic views of proteins

Alzheimer’s protein turns up as potential target for autism treatments

by  /  2 March 2020

Lowering the levels of a protein called tau, best known for its involvement in Alzheimer’s disease, improves behavior in two mouse models of autism.

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February 2020

Large mutations may explain diverse outcomes from autism gene

by  /  24 February 2020

Deletions and duplications of long stretches of DNA may increase the likelihood of autism in people who have a mutation in a gene called PTEN.

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November 2019

Mouse study reveals overlooked target for autism therapies

by  /  20 November 2019

Blocking one form of an enzyme implicated in autism eases unusual behaviors and seizures in mice missing a top autism gene.

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Close-up of child's hand on wet window

Mutations in cancer gene tied to unique autism traits

by  /  14 November 2019

Autistic people who carry mutations in a gene called PTEN have distinct behavioral and motor problems.

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October 2019

Transplanted neurons rescue social behavior but not brain circuits

by  /  20 October 2019

Injecting cells called interneurons into the brains of a mouse model of autism restores typical social behavior. But the reason for this effect is a puzzle.

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