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Tag: neural circuits

March 2021
Boy in brain-like tunnel looking towards the light
Features / Deep Dive

Puberty and autism: An unexplored transition

by  /  24 March 2021

Researchers are just beginning to learn what happens in the brains of autistic children during adolescence to explain their unique social, cognitive and emotional challenges.

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February 2021
Mouse brains show different brain regions lighting up
News / Toolbox

Ultrasound probe reveals brain circuit activity in living mice

by  /  18 February 2021

A new high-resolution imaging device tracks brain activity in awake mice, enabling researchers to map neural circuits across the entire brain.

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January 2021
Mouse brain slices shown in red
News

Vasopressin relieves social deficits in an autism mouse model

by  /  25 January 2021

Mice missing a copy of MAGEL2 have trouble discerning between a familiar mouse and an unfamiliar one; treating them with the social hormone vasopressin reverses this deficit.

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lab mice
News

Mice with autism-related mutations show brain signaling imbalance

by  /  4 January 2021

Mutations in POGZ, a gene strongly linked to autism, lead to a signaling imbalance in multiple brain regions in mice, according to two new studies.

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December 2020
Micrograph of nerve cells being targeted by CRISPR enzyme to activate the silenced gene in Angelman syndrome
Features / Special Reports / Hindsight is 2020: The year in review

Hot topics in autism research, 2020

23 December 2020

The Spectrum team highlights five topics that distinguished autism research in 2020: diversity in data, gene therapies, subtyping, social circuitry and the ‘autism gene’ debate.

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Protein in brain
News

Drug helps mice with autism-linked mutation recognize others

by  /  21 December 2020

Mice that model 22q11.2 deletion syndrome lack social memory, but that trait can be reversed using a drug that targets the flow of potassium ions in neurons.

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Oxytocin neurons stained pink and green.
News

Autism-linked gene exerts varied effects on oxytocin circuits in mice

by  /  18 December 2020

Two types of neurons process social information, a new mouse study suggests, but only one is disrupted in mice missing the autism-linked gene FMR1.

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November 2020
Dilated mouse pupil
News

Mice reveal roots of sensory issues tied to top autism gene

by  /  23 November 2020

Mice with mutations in the autism-linked gene SYNGAP1 have trouble sensing touch, which may stem in part from brain-circuit alterations and dulled alertness.

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September 2020
Photograph taken by drone shows Anthony ZAdor and his son running alongside the water.
Opinion / Q&A

Beyond the bench: A conversation with Tony Zador

by  /  29 September 2020

Neuroscientist Tony Zador discusses the enigma of the human brain, the ‘aha’ moments of running and why a ski resort is a good place for a scientific conference.

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Brain images showing differences in signaling in autistic and normal brains.
News

Brain signal imbalance tracks with sex and with camouflaging autism traits

by  /  17 September 2020

Autistic men show a greater imbalance between excitatory and inhibitory signaling in the brain than autistic women do, which could explain sex differences in ‘camouflaging.’

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