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Tag: neural circuits

June 2021
wireless optogenetic device glowing green on mouse brain.
News / Toolbox

Wireless optogenetic devices sync neurons among mice

by  /  17 June 2021

Researchers say they can synchronize two new devices and control neurons across 256 freely moving animals at once to study social behaviors.

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May 2021
Researcher in red plaid shirt and blue nitrile gloves holds a lab mouse fitted with a fiber optic cannula, a needle-shaped glass piece that goes into the mouse's brain surrounded by a metal sleeve to which researchers attach a fiber optic patch cord.
News

How artificial intelligence is shaking up animal behavior studies in autism

by  /  24 May 2021

Next-generation machine-learning tools are poised to upend how scientists study behavior in animal models of autism — and not everyone is happy about it.

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April 2021
Brain scan showing communication from amygdala to hypothalamus about social reward.
News

Brain circuit makes social interactions rewarding, may be altered in autism

by  /  30 April 2021

Blocking connections between the amygdala and hypothalamus prevents mice from finding social interactions as rewarding as they would otherwise.

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A group of six images of fruit fly brains show networks in green and pink.
News

Poor sleep could be core feature of autism, related conditions

by  /  15 April 2021

Fruit flies with low expression of a gene linked to neurodevelopment have disrupted sleep, poor memory and altered social behavior.

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Micrograph comparing locus coeruleus of 16p11.2 mutant mice and control mice show less active noradrenergic neurons in mutant mice.
News

Circuit flaw underlies motor learning issues in autism mouse model

by  /  12 April 2021

Mice missing a copy of chromosomal region 16p11.2 are slow to learn motor tasks and have dysfunction in a brain circuit associated with stress and movement, according to a new study. Normalizing this circuit’s activity corrects the learning deficit.

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March 2021
Boy in brain-like tunnel looking towards the light
Features / Deep Dive

Puberty and autism: An unexplored transition

by  /  24 March 2021

Researchers are just beginning to learn what happens in the brains of autistic children during adolescence to explain their unique social, cognitive and emotional challenges.

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February 2021
Mouse brains show different brain regions lighting up
News / Toolbox

Ultrasound probe reveals brain circuit activity in living mice

by  /  18 February 2021

A new high-resolution imaging device tracks brain activity in awake mice, enabling researchers to map neural circuits across the entire brain.

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January 2021
Mouse brain slices shown in red
News

Vasopressin relieves social deficits in an autism mouse model

by  /  25 January 2021

Mice missing a copy of MAGEL2 have trouble discerning between a familiar mouse and an unfamiliar one; treating them with the social hormone vasopressin reverses this deficit.

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lab mice
News

Mice with autism-related mutations show brain signaling imbalance

by  /  4 January 2021

Mutations in POGZ, a gene strongly linked to autism, lead to a signaling imbalance in multiple brain regions in mice, according to two new studies.

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December 2020
Micrograph of nerve cells being targeted by CRISPR enzyme to activate the silenced gene in Angelman syndrome
Features / Special Reports / Hindsight is 2020: The year in review

Hot topics in autism research, 2020

23 December 2020

The Spectrum team highlights five topics that distinguished autism research in 2020: diversity in data, gene therapies, subtyping, social circuitry and the ‘autism gene’ debate.

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