Cells from people with fragile X syndrome overproduce — but don’t accumulate — proteins. New work suggests that excessive protein breakdown may account for this discrepancy, and explain some of the syndrome’s traits.
Spectrum: Autism Research News
Tag: neural circuits
Rumbaugh, who studies how the autism-linked gene SYNGAP1 shapes brain development, describes how he has embraced coastal living and which aspects of his career he wouldn’t do over.
Having an infection during pregnancy is tied to a small increase in the chances of having an autistic child, but the connection may not be causal.
A new method that merges tissue expansion, light-sheet microscopy and automated image segmentation can reconstruct neural circuits in about a week.
The transplanted cells integrate into living animals’ neural circuitry and influence behavior.
Oxytocin therapies have failed to consistently benefit autistic people, but their effects in people with two autism-linked conditions may yield new insights, experts argue.
People’s brains have a larger network of inhibitory interneurons than mouse brains do, according to a new study. Changes to that network could contribute to autism or other conditions, says lead investigator Moritz Helmstaedter.
The growth differences vary between autistic boys and girls and are most apparent among children with prominent social difficulties.
Therapies that target the circuit could boost social activity, new findings suggest.
Ramping up levels of one isoform of the autism-linked protein reverses traits in model mice, a new study shows.