Alterations in inhibitory circuits and difficulties in social recognition characterize mice missing one copy of DYRK1A, a gene linked to autism.
Spectrum: Autism Research News
Tag: neural circuits
The underlying regional neurobiology of the conditions may differ from person to person.
The map, by far the largest one of an entire brain to date, contains 130,000 neurons and 53 million synapses.
The tool could help researchers study the neurobiology of natural behaviors, scientists say.
Knocking down the gene that codes for the proteins normalizes the vocalizations.
When combined with tissue-inflation methods, the microscope can image axons without the need for tissue slicing, the researchers say.
The discovery could help clinicians diagnose children who carry mutations in the gene, called SCN2A, and gauge their responses to potential therapies.
The framework, inspired by the polygenic risk score, considers the cumulative effect of neuronal connections.
By imaging and recording synaptic activity in living mouse embryos for the first time, new research reveals previously unknown patterns of development and hints at how those patterns are disrupted in autism.
The map diagrams more than half a million neuronal connections in the first complete connectome of Drosophila and holds clues about which brain architectures best support learning.