When Yizhar isn’t building new tools to study the neural circuits underlying autism and other complex conditions, you can find him playing the piano, shooting photographs or taking long runs in the desert.
A new technique can reveal where thousands of neurons send their axons — and measure the cells’ RNA levels for dozens of genes at the same time — in the mouse brain. It could be used to profile neural circuits underlying autism.
When probing the circuits underlying social behavior in animal models of autism, researchers should consider potentially confounding variables, use multiple behavioral assays and report results in a descriptive and unbiased manner.
Thanks to a new engineered protein for optogenetics experiments, researchers can stimulate neurons with less light than usual and avoid damaging brain tissue.
Over the course of a career spanning more than three decades, Huda Zoghbi has won almost every major biology and neuroscience research award that exists. More than 20 years since she discovered the gene behind Rett syndrome, she remains laser focused on unlocking the condition’s secrets and finding effective treatments.
Researchers say they can synchronize two new devices and control neurons across 256 freely moving animals at once to study social behaviors.
Next-generation machine-learning tools are poised to upend how scientists study behavior in animal models of autism — and not everyone is happy about it.
Blocking connections between the amygdala and hypothalamus prevents mice from finding social interactions as rewarding as they would otherwise.
Fruit flies with low expression of a gene linked to neurodevelopment have disrupted sleep, poor memory and altered social behavior.
Mice missing a copy of chromosomal region 16p11.2 are slow to learn motor tasks and have dysfunction in a brain circuit associated with stress and movement, according to a new study. Normalizing this circuit’s activity corrects the learning deficit.