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Spectrum: Autism Research News

Tag: neural circuits

October 2023
A research image of a mouse hippocampus

Some social issues in DYRK1A model mice stem from faulty inhibitory circuits

by  /  11 October 2023

Alterations in inhibitory circuits and difficulties in social recognition characterize mice missing one copy of DYRK1A, a gene linked to autism.

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September 2023
Research image of brain scans displaying gray-matter volume differences across across six psychiatric conditions.

Alterations in circuits characterize six neuropsychiatric conditions

by  /  13 September 2023

The underlying regional neurobiology of the conditions may differ from person to person.

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August 2023
A research image of the fly brain connectome

Full connectome of adult fruit fly completed, with help from citizen scientists

by  /  7 August 2023

The map, by far the largest one of an entire brain to date, contains 130,000 neurons and 53 million synapses.

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Still image from a video of a mouse maneuvering a robot around a maze while imaging tools capture neuronal activity in its cortex.

Robotic headgear records brain activity in moving mice

by  /  3 August 2023

The tool could help researchers study the neurobiology of natural behaviors, scientists say.

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July 2023
Research image of neurons.

Abundant motor proteins disrupt cries in FOXP2 mice

by ,  /  28 July 2023

Knocking down the gene that codes for the proteins normalizes the vocalizations.

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Repurposed electronics lens spies neurons across entire mouse brain

by  /  14 July 2023

When combined with tissue-inflation methods, the microscope can image axons without the need for tissue slicing, the researchers say.

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A slice of a cerebellum

Mutation in top autism-linked gene may alter eye reflex

by  /  7 July 2023

The discovery could help clinicians diagnose children who carry mutations in the gene, called SCN2A, and gauge their responses to potential therapies.

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June 2023
Research image of brain scans showing connections in the brain in different colors.

Statistical method improves behavioral predictions from fMRI

by  /  29 June 2023

The framework, inspired by the polygenic risk score, considers the cumulative effect of neuronal connections.

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April 2023
Research image of cortical structures in mice.

Autism-linked mutations scramble nascent cortical circuits

by  /  17 April 2023

By imaging and recording synaptic activity in living mouse embryos for the first time, new research reveals previously unknown patterns of development and hints at how those patterns are disrupted in autism.

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March 2023
Still from research video displaying wiring map of a fruit fly's brain.

Wiring map reveals how larval fruit fly brain converts sensory signals to movement

by  /  9 March 2023

The map diagrams more than half a million neuronal connections in the first complete connectome of Drosophila and holds clues about which brain architectures best support learning.

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