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Tag: BTBR mice

November 2013
News

Diet and drug alleviate symptoms in autism rat models

by  /  12 November 2013

Two studies in autism rat models suggest that a high-fat, low-carbohydrate diet and an unapproved drug for dementia may improve some symptoms of the disorder, according to unpublished results presented Sunday at the 2013 Society for Neuroscience annual meeting in San Diego.

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News

‘Humanized’ mouse assays reveal subtle behaviors

by  /  10 November 2013

A new test of mouse intelligence closely mimics the types of assays used with people and detects a subtle learning deficit reminiscent of one seen in teenagers with autism, according to findings presented Saturday at the 2013 Society for Neuroscience annual meeting in San Diego.

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October 2013
News / Toolbox

New behavioral test uncovers autism mouse’s stubbornness

by  /  2 October 2013

Researchers have developed a new test that reveals complex repetitive behaviors in BTBR mice, a mouse strain with features resembling those of autism, according to a study published 27 August in the Journal of Neuroscience Methods.

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August 2013
News

Cognition and behavior: Diet makes autism mouse friendly

by  /  16 August 2013

Eating a high-fat, low-carbohydrate — or ‘ketonogenic’ — diet for five weeks makes a mouse model of autism more sociable, according to a study published 5 June in PLoS One. The results suggest that this diet may be beneficial for children with autism.

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May 2013
News

Molecular mechanisms: Mice link brain region to autism

by  /  21 May 2013

A strain of mice with autism-like behaviors is missing a corpus callosum, a bundle of nerve fibers that connects the two hemispheres of the brain. Two studies published this month investigate the link between these two features.

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News

Cognition and behavior: Social deficits may develop in utero

by  /  3 May 2013

Exposure to immune factors during gestation may account for the social deficits seen in a mouse model of autism, according to a study published 15 May in the Journal of Neuroimmunology. Fetuses of a normal mouse strain develop the same social deficits when exposed to the immune factors.

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News

Reward study questions autism mouse model’s relevance

by  /  2 May 2013

The BTBR mouse model, an asocial strain often used to study autism, may not be optimal for autism research, suggests an unpublished study presented today at the 2013 International Meeting for Autism Research in San Sebastián, Spain.

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News

Lack of corpus callosum yields insights into autism

by  /  2 May 2013

A rare birth defect offers a unique perspective on the connectivity theory of autism. Up to one-third of those missing all or part of the corpus callosum, a thick tract of nerve fibers connecting the left and right brain hemispheres, meet the diagnostic criteria for autism, several recent studies suggest.

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December 2012
News

Molecular mechanisms: Star cells abnormal in autism brains

by  /  7 December 2012

Postmortem brains from individuals with autism have astrocytes that are smaller but denser than in control brains, according to a study published 21 September in the Journal of Neuroinflammation. The researchers found similar alterations in a mouse that lacks the autism-linked gene NLGN3.

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October 2012
News

Acetylcholine drug alleviates autism-like behaviors in mice

by  /  16 October 2012

A drug that mimics the neurotransmitter acetylcholine relieves repetitive behaviors in a mouse model of autism, according to a poster presented Monday at the Society for Neuroscience annual meeting in New Orleans.

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