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Spectrum: Autism Research News

Tag: 15q11-13

August 2012

Chromosome 15 duplications common in autism

by  /  30 August 2012

About 1 in 500 children referred to genetic testing for undefined developmental delay, intellectual disability, or autism have duplications of the 15q11-13 chromosomal region, according to a new analysis. That makes the region the second most common large genetic alteration linked to autism.


Genes and environment are two-way street in autism risk

by  /  21 August 2012

Genes and the environment each influence the role of the other in determining the risk of developing autism. Genetics can determine how susceptible one is to the environment, and environmental factors can influence gene expression and introduce mutations, says immunologist Janine LaSalle.


Researchers eye pigs for modeling autism-related disorder

by  /  13 August 2012

Researchers plan to develop pig models of Prader-Willi syndrome, an inherited disorder caused by the deletion of an autism-linked region of chromosome 15.


Researchers home in on dosage effects of 15q11-13 region

by  /  13 August 2012

Researchers are beginning to tease apart how dosage of genes within the 15q11-13 chromosomal region contributes to autism symptoms.

A white mouse stands on its hind legs against a green background.

Nonprofit rallies funds to create autism-related mouse model

by  /  9 August 2012

Concerned by researchers’ lack of access to a valuable mouse model of autism, a nonprofit advocacy group is dedicating a chunk of its limited resources to the creation of a freely available version.

June 2012

Molecular mechanisms: Alzheimer’s protein linked to autism

by  /  22 June 2012

Amyloid-beta, the small protein that forms plaques in the brains of people with Alzheimer’s disease, is more prevalent in postmortem brains from individuals with autism than in those from controls, according to a study published 2 May in PLoS One.


Genetics: Analysis identifies new autism candidate regions

by  /  19 June 2012

An analysis of large duplications and deletions of DNA has identified new candidate genes for autism in pathways linked to the disorder. The results were published 22 May in Human Molecular Genetics.

February 2012

SHANK2 study bolsters ‘multi-hit’ gene model of autism

by  /  13 February 2012

By screening the genomes of hundreds of people with autism and analyzing the effects of newly identified mutations in cultured neurons, researchers have clarified the disorder’s link to the SHANK2 gene.

January 2012

Funding fears prevent researchers from sharing their mice

by  /  9 January 2012

Despite funders’ requirements to share mouse models after publication, many researchers hoard the animals for the good of their labs — and that could have an adverse effect on the field as a whole.

December 2011

Genetics: Small DNA region implicated in autism

by  /  6 December 2011

Duplication or deletion of four genes within a large chromosomal region linked to Angelman syndrome and autism could lead to developmental disability or language delay, according to a study published in the October issue of Human Genetics.