Varying the number of copies of a single autism-linked gene modulates social behavior and aggression in mice, according to unpublished results presented yesterday at the 2014 Society for Neuroscience annual meeting in Washington, D.C.
Spectrum: Autism Research News
A rare form of autism linked to a duplication of the 15q11-13 chromosomal region shares a molecular signature with more common forms of the disorder, suggests unpublished research presented yesterday at the 2014 Society for Neuroscience annual meeting in Washington, D.C.
Mice with an extra copy of the autism-linked gene UBE3A show abnormal social behavior after experiencing recurrent seizures. The findings, presented Tuesday at the Autism Consortium Research Symposium in Boston, provide one possible explanation for why seizures and autism often go hand in hand.
Neurologist Lawrence Reiter is growing neurons from the discarded teeth of children with neurological syndromes. Here he describes how dental pulp may help researchers find the genes and pathways that underlie autism symptoms.
To characterize people who carry deletions in 16p11.2 and 15q13.3, genetic regions linked to autism, two studies published this summer looked in detail at dozens of people with either deletion. The studies found that deletions in these regions lead to diverse symptoms that only sometimes include autism.
People with duplications of the 15q11-13 chromosomal region, which is linked to certain neurological disorders, can experience a variety of seizures, according to a study published 6 February in Epilepsia. They may also respond better to some seizure medications than others.
Mutations in FAN1, a gene in the 15q13.3 chromosomal region, raise the risk of neuropsychiatric disorders including autism and schizophrenia, according to a new study published 7 January in the Proceedings of the National Academy of Sciences.
Mutations in a single gene in 15q11.13 — a chromosomal region linked to multiple neurological disorders — may increase the risk of autism, according a study published in November in Nature Genetics.