Tag: 15q11-13

July 2019
Orange patterns are created from chemical tags in brain tissue from people with autism.
News

Different forms of autism may share pattern of chemical tags on DNA

by  /  22 July 2019

Brain tissues from people with autism of unknown cause and from people with either of two genetic forms of the condition all show similar patterns of methyl groups on DNA.

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News

Gene linked to multiple forms of autism may boost risk of death from seizures

by  /  18 July 2019

Mice with extra copies of UBE3A, a gene linked to autism and related conditions, are susceptible to death from seizures.

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January 2019
Researchers and doctors interacting with family with genetic syndrome
Opinion / Viewpoint

Reaching out to families can inspire new autism research

by  /  29 January 2019

For students and early-career investigators, opportunities to meet and talk with the people they are trying to help underscores why the work matters.

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October 2018
Brain cells under magnification glow red, purple and blue.
News

Mini-brains may pin down key genes in large mutations

by  /  22 October 2018

Clusters of brain cells — so-called ‘mini-brains’ grown in the lab — may help researchers understand how large stretches of duplicated or deleted DNA affect the brain.

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August 2018
Kids shoes in hallway showing one boy standing alone by a group.
News

Rare duplication within chromosome 15 delivers relatively mild blow

by  /  7 August 2018

Children who have a rare extra copy of one segment on chromosome 15 have better cognitive abilities and daily living skills than those with a duplication that forms an extra chromosome.

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January 2018
Neurons missing a part of chromosome 16 (left) are larger and have more branches than control neurons (middle); neurons with duplications of the region are small and sport short dendrites (right).
News

Lab-grown neurons showcase effects of autism mutations

by  /  15 January 2018

Neurons derived from people with mutations linked to autism display diverse abnormalities that may help explain the origins of these individuals’ features.

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November 2017
Stack of filing boxes with papers going from one to another.
News

Registry for autism-linked syndrome spurs new research

by  /  2 November 2017

Nine U.S. clinics are pooling their data to create a registry of people who have an extra copy of a region on chromosome 15 called 15q11-13, a genetic abnormality often found in people with autism.

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Brain bank slice of brain in lab
Features / Deep Dive

Banking on brains for clues to autism

by  /  1 November 2017

New initiatives aim to increase brain donations for autism research and maximize what scientists can learn from these precious specimens.

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October 2017
Toddler girl sleeping with hair floating against black background.
Opinion / Viewpoint

How treating sleep may ease all forms of autism

by  /  31 October 2017

Behavioral interventions and medications can help children with autism-related syndromes sleep better, but the treatments must be tailored to the cause of each child’s sleep disturbance.

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July 2017
News

Antidepressant eases some autism features in mice

by  /  28 July 2017

A drug that keeps neurons bathed in the chemical messenger serotonin prevents social abnormalities in a mouse model of dup15q syndrome.

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