Cells with excess UBE3A, an autism-linked protein, have atypical firing properties that can be corrected by limiting the protein’s levels, according to new research.
Children with dup15q syndrome may have telltale patterns of brain activity during sleep and get less non-REM sleep than neurotypical children do.
A collection of rare genetic variants associated with autism and schizophrenia also seem to increase a person’s odds of having attention deficit hyperactivity disorder.
Brain tissues from people with autism of unknown cause and from people with either of two genetic forms of the condition all show similar patterns of methyl groups on DNA.
Mice with extra copies of UBE3A, a gene linked to autism and related conditions, are susceptible to death from seizures.
For students and early-career investigators, opportunities to meet and talk with the people they are trying to help underscores why the work matters.
Clusters of brain cells — so-called ‘mini-brains’ grown in the lab — may help researchers understand how large stretches of duplicated or deleted DNA affect the brain.
Children who have a rare extra copy of one segment on chromosome 15 have better cognitive abilities and daily living skills than those with a duplication that forms an extra chromosome.
Neurons derived from people with mutations linked to autism display diverse abnormalities that may help explain the origins of these individuals’ features.
Nine U.S. clinics are pooling their data to create a registry of people who have an extra copy of a region on chromosome 15 called 15q11-13, a genetic abnormality often found in people with autism.