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Spectrum: Autism Research News

Tag: 15q11-13

November 2021
UBE3A expression in mouse brain slices, shown in green.

One-shot gene therapy for Angelman syndrome shows promise in mice

by  /  29 November 2021

A potential new gene therapy delivered via a single injection mimics ratios of proteins normally found in cells.

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Dispatches from SfN 2021: Mitochondria, Rett therapy and oxytocin

These short reports from Spectrum journalists highlight some of the autism-related findings that caught our attention at the meeting this past week.

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January 2021
Illustration of firing neurons.

Autism protein may shape neuronal firing patterns

by  /  14 January 2021

Cells with excess UBE3A, an autism-linked protein, have atypical firing properties that can be corrected by limiting the protein’s levels, according to new research.

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Boy sleeping in low light

Brain-wave patterns flag sleep differences in dup15q syndrome

by  /  13 January 2021

Children with dup15q syndrome may have telltale patterns of brain activity during sleep and get less non-REM sleep than neurotypical children do.

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November 2019
Strand of DNA with bases being deleted

Autism-linked gene variants increase odds of attention deficit

by  /  18 November 2019

A collection of rare genetic variants associated with autism and schizophrenia also seem to increase a person’s odds of having attention deficit hyperactivity disorder.

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July 2019
Orange patterns are created from chemical tags in brain tissue from people with autism.

Different forms of autism may share pattern of chemical tags on DNA

by  /  22 July 2019

Brain tissues from people with autism of unknown cause and from people with either of two genetic forms of the condition all show similar patterns of methyl groups on DNA.

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Gene linked to multiple forms of autism may boost risk of death from seizures

by  /  18 July 2019

Mice with extra copies of UBE3A, a gene linked to autism and related conditions, are susceptible to death from seizures.

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January 2019
Researchers and doctors interacting with family with genetic syndrome

Reaching out to families can inspire new autism research

by  /  29 January 2019

For students and early-career investigators, opportunities to meet and talk with the people they are trying to help underscores why the work matters.

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October 2018
Brain cells under magnification glow red, purple and blue.

Mini-brains may pin down key genes in large mutations

by  /  22 October 2018

Clusters of brain cells — so-called ‘mini-brains’ grown in the lab — may help researchers understand how large stretches of duplicated or deleted DNA affect the brain.

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August 2018
Kids shoes in hallway showing one boy standing alone by a group.

Rare duplication within chromosome 15 delivers relatively mild blow

by  /  7 August 2018

Children who have a rare extra copy of one segment on chromosome 15 have better cognitive abilities and daily living skills than those with a duplication that forms an extra chromosome.

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