Activating the immune system blunts social behavior in mice missing a copy of the autism-linked gene SHANK3, according to a new study. Blocking TRPV4, which encodes an ion channel involved in inflammatory responses, can reverse this effect.
Spectrum: Autism Research News
Mutations in all three accelerate the maturation of inhibitory neurons, which could upset the brain’s balance of excitation and inhibition early in development.
Model animals don’t develop the usual behavioral and motor problems when reared in an enclosure containing exercise wheels, toys and treats.
A researcher and science officer give tips for getting started with grant writing; scientists on Twitter explain why they went tenure-track; and a neurobiologist discusses why the field’s next generation needs to learn to code.
The protein, FMRP, shapes cell signaling near synapses but switches to regulate genes in the cell body, according to new research.
This week’s Community Newsletter takes up tweets about how often autism intervention research fails to report participants’ race and ethnicity, benchmarks for effect sizes and mapping chandelier cells in the mouse visual cortex.
Some copy number variants may boost a person’s chances of having autism, but to a lesser extent than previously thought.
Mice missing a copy of the gene ASH1L have excess synapses and autism-like behavioral differences, some of which are reversed by boosting an ASH1L-regulated gene.
Girls and young women with Rett syndrome have less severe anxiety and breathing problems after treatment with trofinetide, an analogue of insulin-like growth factor 1, according to an unpublished placebo-controlled trial.
A failed replication and other problems led autism researcher Beth Stevens and her co-investigator to retract the nearly 10-year-old report.