An experimental drug improves sensory sensitivities in fragile X model mice — but only if it’s administered after certain brain circuits have formed, according to a new unpublished study.
Spectrum: Autism Research News
The variants are associated with slight differences in measures of intelligence, income and employment, but the relationship may not be causal.
As acetaminophen lawsuits make their way through the U.S. court system, researchers reevaluate the quality of the evidence linking in-utero exposure to the painkiller to neurodevelopmental issues in children.
Contrary to conventional wisdom, most people with fragile X syndrome express the FMR1 gene — albeit improperly.
But multiple independent researchers say they are not convinced by its results, which fail to confirm high-profile findings from 2017.
This week on social media, researchers discussed sample size in neuroimaging studies and the potential of antisense oligonucleotides to restore the protein lost in fragile X syndrome.
The discovery could help clinicians diagnose children who carry mutations in the gene, called SCN2A, and gauge their responses to potential therapies.
Nonrandom mating — the propensity for people to partner with others who share their traits — can increase the likelihood of autism or other conditions across generations.
Zhao says her graduate and postdoctoral training prepared her to transition to her job at the biotech company Ionis Pharmaceuticals, where she works to find treatments for Parkinson’s disease and other conditions.
The approach prompts cultured cells to correct the genetic mutation in fragile X syndrome using their own DNA repair system, but it still needs to be tested further.