Mutations in two genes linked to autism, neurexin and neuroligin, slow down neuronal signaling, according to research published 2 August in Science. Analyzing the mutations in the nematode Caenorhabditis elegans, the study found that mutations in these genes affect signaling in the opposite direction than is typical.

Pregnant rats exposed to a virus give birth to offspring with significantly altered levels of three proteins important for brain development, according to a study published 9 June in Molecular Brain.

A pH-sensitive red fluorescent molecule allows researchers to simultaneously monitor two different types of neuronal activity, according to a study published 27 May in Nature Neuroscience.

Researchers have mapped networks of genes expressed at the same time and place in the brain and shown that rare and common autism-linked mutations are likely to function in the same pathways. The results were published 8 March in PLoS Genetics.

An elegant microscopy technique reveals that neurons can regulate how quickly they recycle chemical messengers, according to a study published in July in Nature Neuroscience. This process is believed to be the limiting step in the speed of signaling across neuronal junctions.

Soluble proteins band together into temporary complexes to travel to the tips of neurons, according to a study published 12 May in Neuron. The study provides the first evidence-based model for slow, directed neuronal transport, answering a long-standing question in the field.

Exosomes, the brain’s system for delivering and recycling molecules, can be manipulated to carry therapeutic fragments of RNA or DNA across the blood-brain barrier and into neurons. The ingenious new technique was published 20 March in Nature Biotechnology.

A chilling new technique shows the intricate and coordinated activity of previously mysterious pieces of the synapse, the all-important junction between neurons that allows cells to talk to each other.