Tag: synaptic plasticity

July 2013

Molecular mechanisms: Autism mutation alters brain links

by  /  30 July 2013

Newborn mice with an autism-linked mutation in neuroligin-3, which stabilizes junctions between neurons, have abnormal brain chemistry, according to a study published 4 June in Frontiers in Cellular Neuroscience.

June 2013
Multimedia / Webinars

Kimberly Huber on synapse pruning in autism

26 June 2013

Watch the complete replay of Kimberly Huber discussing the role of autism-linked genes in the natural pruning of brain cell connections. Submit your own follow-up questions.

May 2013
Opinion / Viewpoint

Small pieces of RNA may pave path to autism

by  /  21 May 2013

The discovery of microRNAs that regulate gene expression has changed our view of cellular biochemistry. It may also change our perception of neuropsychiatric disorders such as autism, says Peng Jin.

News / Toolbox

Light toggles function of signaling proteins

by  /  1 May 2013

Researchers can use light to activate certain proteins that receive signals at the junctions between neurons and that are key targets for fragile X syndrome therapies, according to a study published in the April issue of Nature Neuroscience.

April 2013

Studies show promise for fragile X treatment

by  /  25 April 2013

Researchers have added two new candidates to the arsenal of compounds that alleviate both the behavioral and molecular hallmarks of fragile X syndrome in mice that model the disorder. A third candidate, minocycline, improves some symptoms in children with the disorder.

March 2013
Opinion / Viewpoint

Rho family of enzymes at crossroads of autism

by  /  12 March 2013

A number of autism risk factors converge on one cellular pathway: abnormal remodeling of the cell’s structural systems through the signaling protein Rho, says SFARI’s associate director for research, Alan Packer.

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February 2013
Opinion / Viewpoint

Flexible brain

by  /  8 February 2013

Transcranial magnetic stimulation may provide a noninvasive approach to studying how connections in the human brain change in response to new information, and how that process is altered in autism, says Lindsay Oberman.


Molecular mechanisms: Pruning path links autism, fragile X

by  /  1 February 2013

The protein lacking in fragile X syndrome works with three autism-linked proteins to fine-tune the connections between neurons, according to a study published 21 December in Cell.

January 2013

Hunt for targets of fragile X protein proves perplexing

by  /  31 January 2013

FMRP, the protein missing in fragile X syndrome, binds to the RNA sequences of 939 genes, 93 of which have been linked to autism, according to a study published 20 December in Nature.

December 2012

Molecular mechanisms: Star cells abnormal in autism brains

by  /  7 December 2012

Postmortem brains from individuals with autism have astrocytes that are smaller but denser than in control brains, according to a study published 21 September in the Journal of Neuroinflammation. The researchers found similar alterations in a mouse that lacks the autism-linked gene NLGN3.