Microglial overreaction to atypical neurons may drive autism
In mice and organoids lacking a neuronal protein, microglia prune synapses to excess.
In mice and organoids lacking a neuronal protein, microglia prune synapses to excess.
The tool — called “MouseGoggles” — could provide rodents with an improved virtual experience in the lab, at a lower cost than current techniques.
Alterations in inhibitory circuits and difficulties in social recognition characterize mice missing one copy of DYRK1A, a gene linked to autism.
Increasing or reducing the levels of the UBE3A gene, which is associated with autism and autism-related syndromes, results in altered patterns of synaptic pruning — a process that snips away brain cell connections.
A thin “micro-tether” and rotating connector facilitate uninterrupted, hours-long neural population recordings as the animals freely explore their environment.
Synaptic changes in the brain region could drive a core trait of fragile X syndrome, a new mouse study suggests.
A protective pathway that pauses protein synthesis is muted in a mouse model of fragile X syndrome, according to a new study.
Brain scans of hundreds of infants suggest that up to 80 percent of those with autism have unusual amounts of cerebrospinal fluid. Researchers are studying how this might contribute to the condition.
Over one hour, a particularly motivated mouse poked its nose 350 times into a hole in the test chamber in the hopes of meeting a playmate.
The tool could help researchers study the neurobiology of natural behaviors, scientists say.