A genetic panel intended to predict the risk of developing autism debuted for clinical use in April, while another is in commercial development and a third was published in Molecular Psychiatry in September. But some experts are concerned, saying the tests are based on preliminary scientific evidence.
Researchers have used stem cells to identify 801 neuronal genes that are preferentially expressed from either the maternal or paternal chromosome, according to a study published 30 August in PLoS One. Of these genes, 26 are linked to autism and 48 to schizophrenia.
Activating the expression of FMR1, the gene mutated in fragile X syndrome, in adult mice reverses symptoms of the syndrome, according to a poster presented Monday at the Society for Neuroscience annual meeting in New Orleans.
Individuals with an extra copy of MeCP2, the gene mutated in Rett syndrome, have severe developmental delay accompanied by seizures, respiratory infections, poor motor skills and features of autism, according to two new case studies.
An in-depth analysis of tissue from a large number of autism brains eases some of the qualms about their use in research, according to a poster presented Monday at the 2012 Society for Neuroscience annual meeting in New Orleans.
Rapid progress in gene discovery and an emerging map of the molecular landscape of normal brain development are presenting unprecedented opportunities to unravel the biology of autism spectrum disorders, say Matthew State and Nenad Sestan.
Some song-related areas in the zebra finch brain and language areas in the human brain show strikingly similar patterns of gene expression, according to unpublished research presented Sunday at the Society for Neuroscience annual meeting in New Orleans.
An analysis of the expression patterns of 26 autism candidate genes identifies 4 whose expression coincides in a part of the cerebellum, according to research presented at the 2012 Society for Neuroscience annual meeting in New Orleans.
The sperm of old mice has an unusual epigenome, the profile of chemical modifications to the underlying DNA code, according to a poster presented Saturday at the 2012 Society for Neuroscience annual meeting in New Orleans. The findings suggest an explanation for the so-called paternal age effect in autism.
RNA editing, which creates multiple forms of a protein, is common among proteins involved in neuronal signaling, and may be abnormal in people with autism, according to a study published 7 August in Molecular Psychiatry.