Cells from people with fragile X syndrome overproduce — but don’t accumulate — proteins. New work suggests that excessive protein breakdown may account for this discrepancy, and explain some of the syndrome’s traits.
Spectrum: Autism Research News
Using imaging methods to sort mouse models of autism may help identify subtypes of autistic people with similar underlying biology.
Pagani used mouse models to connect autism etiologies to brain connectivity alterations and then found similar alterations in people with idiopathic forms of the condition.
The circuit linking the prefrontal cortex and part of the thalamus is impaired in mice raised in social isolation and in mice with mutations in the FMR1 or TSC2 genes.
Collecting brain scans from thousands of people can be challenging in autism research; data-sharing and collaborative efforts can help drive results that stand up to statistical scrutiny.
The transplanted cells integrate into living animals’ neural circuitry and influence behavior.
The results highlight the importance of subgrouping study participants based on their underlying genetics, the researchers say.
The method could boost reproducibility across brain imaging studies of autism.
Therapies that target the circuit could boost social activity, new findings suggest.
Statistical modeling and machine learning helps blunt the bias in brain imaging studies that exclude young autistic children and those with prominent traits, a new study finds.