Autism-linked mutation alters neuronal network activity
Neurons with a faulty copy of SETD1A, a gene tied to autism and schizophrenia, show structural abnormalities and altered connectivity patterns.
Neurons with a faulty copy of SETD1A, a gene tied to autism and schizophrenia, show structural abnormalities and altered connectivity patterns.
The ‘projectome’ charts axonal pathways between individual cells in the prefrontal cortex, a brain region implicated in autism.
Deep-learning algorithms can cut through some of the noise in brain imaging data collected across different sites.
Targeting the molecule, 4EPS, with an experimental drug may be a way to ease anxiety for autistic people, the researchers say. But not everyone is convinced.
A modified version of a probe commonly used in animals detected neuronal activity across different cortical layers in three people undergoing brain surgery.
Model mice of the subtype also show hyperactivity in a signaling pathway called mTOR, bolstering the idea that distinct forms of autism have different biological roots and may require different treatment approaches.
These short reports from Spectrum journalists highlight some of the autism-related findings that caught our attention at the meeting this past week.
Jolting a bundle of nerve fibers deep in the brain restores learning and memory in mice with mutations of the autism-linked gene CDKL5.
Four subtypes lend new support to the idea that there isn’t a single ‘hallmark’ type of brain connectivity in people with autism.
Mice missing the autism-linked gene SHANK3 use more neurons to engage in social behavior than control mice do, reflecting a more disorganized, less efficient brain signaling network.