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Spectrum: Autism Research News

Tag: connectivity

June 2022
black-and-white image of a burst of neuron activity, indicated by the neurons flashing brightly and simultaneously

Autism-linked mutation alters neuronal network activity

by  /  7 June 2022

Neurons with a faulty copy of SETD1A, a gene tied to autism and schizophrenia, show structural abnormalities and altered connectivity patterns.

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May 2022
3D rendering of a mouse brain showing axons coming from the prefrontal cortex in various colors.

New atlas maps neuronal wiring in mouse brain

by  /  3 May 2022

The ‘projectome’ charts axonal pathways between individual cells in the prefrontal cortex, a brain region implicated in autism.

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March 2022

Neural network finds markers of autism, gender in brain scans

by  /  24 March 2022

Deep-learning algorithms can cut through some of the noise in brain imaging data collected across different sites.

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February 2022

Gut molecule linked to decreased myelination in mouse brains

by  /  14 February 2022

Targeting the molecule, 4EPS, with an experimental drug may be a way to ease anxiety for autistic people, the researchers say. But not everyone is convinced.

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Probe captures neuronal conversations in people

by  /  9 February 2022

A modified version of a probe commonly used in animals detected neuronal activity across different cortical layers in three people undergoing brain surgery.

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November 2021

Synaptic overgrowth, hyperconnectivity may define autism subtype

by  /  18 November 2021

Model mice of the subtype also show hyperactivity in a signaling pathway called mTOR, bolstering the idea that distinct forms of autism have different biological roots and may require different treatment approaches.

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Dispatches from SfN 2021: Mitochondria, Rett therapy and oxytocin

These short reports from Spectrum journalists highlight some of the autism-related findings that caught our attention at the meeting this past week.

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October 2021
Black CDKL5 mice in a lab setting--three mice in a cage.

Brain stimulation improves memory in autism mouse models

by  /  15 October 2021

Jolting a bundle of nerve fibers deep in the brain restores learning and memory in mice with mutations of the autism-linked gene CDKL5.

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September 2021
Colorful image of a composite of multiple brain scans showing communication patterns in different regions.

Autism mouse models cluster by brain activity pattern

by  /  10 September 2021

Four subtypes lend new support to the idea that there isn’t a single ‘hallmark’ type of brain connectivity in people with autism.

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June 2021
Mouse neuron recordings showing different levels of activity before and after an encounter with an unfamiliar mouse.

Neural network captures noisy neurons in autism mouse model

by  /  18 June 2021

Mice missing the autism-linked gene SHANK3 use more neurons to engage in social behavior than control mice do, reflecting a more disorganized, less efficient brain signaling network.

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