Microglial overreaction to atypical neurons may drive autism
In mice and organoids lacking a neuronal protein, microglia prune synapses to excess.
In mice and organoids lacking a neuronal protein, microglia prune synapses to excess.
The map, by far the largest one of an entire brain to date, contains 130,000 neurons and 53 million synapses.
The tool could help researchers study the neurobiology of natural behaviors, scientists say.
When combined with tissue-inflation methods, the microscope can image axons without the need for tissue slicing, the researchers say.
The framework, inspired by the polygenic risk score, considers the cumulative effect of neuronal connections.
Few studies have tracked how brain structure and function change across adulthood in people with autism. Carper and her colleagues are collecting data to fill this gap.
The new resource aims to aid reproducibility in imaging research.
In this edition of Null and Noteworthy, researchers upend early interventions and diagnostic boundaries.
A machine-learning technique applied to brain imaging data appears to predict a person’s mix of verbal intelligence, social affect and repetitive behaviors.
The map diagrams more than half a million neuronal connections in the first complete connectome of Drosophila and holds clues about which brain architectures best support learning.